2 documents found, page 1 of 1
Trypanosoma cruzi in the chicken model : Chagas-like heart disease in the absen...
Teixeira, Antonio Raimundo Lima Cruz; Gomes, Clever; Nitz, Nadjar; Sousa, Alessandro O.; Alves, Rozeneide M.; Guimaro, Maria C.; Cordeiro, CiroBackground: The administration of anti-trypanosome nitroderivatives curtails Trypanosoma cruzi infection in Chagas disease patients, but does not prevent destructive lesions in the heart. This observation suggests that an effective treatment for the disease requires understanding its pathogenesis. Methodology/Principal Findings: To understand the origin of clinical manifestations of the heart disease we used a ...
Inheritance of DNA transferred from American Trypanosomes to human hosts
Hecht, Mariana M.; Nitz, Nadjar; Araujo, Perla F.; Sousa, Alessandro O.; Rosa, Ana de Cássia; Gomes, Dawidson A.; Leonardecz, EduardoInterspecies DNA transfer is a major biological process leading to the accumulation of mutations inherited by sexual reproduction among eukaryotes. Lateral DNA transfer events and their inheritance has been challenging to document. In this study we modified a thermal asymmetric interlaced PCR by using additional targeted primers, along with Southern blots, fluorescence techniques, and bioinformatics, to identif...