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Effect of iontophoresis on fluoride uptake in enamel with artificial caries lesion
Pauli,Maria Cibelle; Tabchoury,Cínthia Pereira Machado; Silva,Silas Arandas Monteiro e; Ambrosano,Gláucia Maria Bovi; Lopez,Renata Fonseca ViannaAbstract: Iontophoresis is a noninvasive technique, based on the application of a constant low-intensity electric current to facilitate the release of a variety of drugs, whether ionized or not, through biological membranes. The objective of this research was to evaluate the effect of iontophoresis using different electric current intensities on the uptake of fluoride in dental enamel with artificial caries les...
Princípios básicos e aplicação da iontoforese na penetração cutânea de fármacos
Gratieri,Taís; Gelfuso,Guilherme Martins; Lopez,Renata Fonseca ViannaPhysicochemical constraints severely limit the number of molecules that can be considered as candidates for transdermal delivery. Iontophoresis is a non-invasive technique in which a weak electric current is used to enhance the penetration of molecules into or through the skin. In this review the underlying mechanisms that drive iontophoresis and the impact of key experimental parameters - namely, formulation, ...