73 documents found, page 1 of 8
Chitosan-based hierarchical scaffolds crosslinked with genipin
Piaia, Lya; Silva, Simone S.; Fernandes, Emanuel Mouta; Gomes, Joana M.; Franco, Albina Ribeiro; Leonor, I. B.; Fredel, Márcio C.; Salmoria, Gean V.Osteochondral defects present significant challenges for effective tissue regeneration due to the complex composition of bone and cartilage. To address this challenge, this study presents the fabrication of hierarchical scaffolds combining chitosan/β-tricalcium phosphate (β-TCP) to simulate a bone-like layer, interconnected with a silk fibroin layer to mimic cartilage, thus replicating the cartilage-like laye...
Innovative antibacterial, photocatalytic, titanium dioxide microstructured surf...
Vieira, Ana; Rodríguez-Lorenzo, Laura; Leonor, I. B.; Reis, R. L.; Espiña, Begoña; Santos, Marília Barreiros dosBacterial colonization and biofilm formation are found on nearly all wet surfaces, representing a serious problem for both human healthcare and industrial applications, where traditional treatments may not be effective. Herein, we describe a synergistic approach for improving the performance of antibacterial surfaces based on microstructured surfaces that embed titanium dioxide nanoparticles (TiO2 NPs). The sur...
Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue eng...
Piaia, Lya; Silva, Simone S.; Gomes, Joana M.; Franco, Albina Ribeiro; Fernandes, Emanuel Mouta; Lobo, Flávia Cristina Marques; Rodrigues, Luísa C.Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable...
Untangling the biological and inflammatory behavior of silk-like sutures In vivo
Franco, Albina Ribeiro; Pirraco, Rogério P.; Fernandes, Emanuel Mouta; Rodrigues, Fernando; Leonor, I. B.; Kaplan, David L.; Reis, R. L.Recombinant spider silk materials with antimicrobial peptides are a promising new class of drug-free antimicrobial materials capable of preventing surgical site infections (SSI), but their potential to impede infections is unclear. Herein, we aimed to unravel the biological and inflammatory potential of bioengineered spider silk materials to prevent SSI using an infection animal model. Silk-like fibers made of ...
A graded, porous composite of natural biopolymers and octacalcium phosphate gui...
Amann, Elisabeth; Amirall, Amisel; Franco, Albina Ribeiro; Poh, Patrina S. P.; Sola Dueñas, Francisco J.; Fuentes Estévez, Gastón; Leonor, I. B.Lesions involving the osteochondral unit are difficult to treat. Biomimetic scaffolds are previously shown as promising alternative. Such devices often lack multiple functional layers that mimic bone, cartilage, and the interface. In this study, multilayered scaffolds are developed based on the use of natural extracellular matrix (ECM)â like biopolymers. Particular attention is paid to obtain a complex matrix t...
Effect of bio-functional MAO layers on the electrochemical behaviour of highly ...
Alves, Alexandra Manuela Vieira Cruz Pinto; Costa, A., I; Toptan, Fatih; Alves, J. L.; Leonor, I. B.; Ribeiro, E.; Reis, R. L.; Pinto, A. M. P.Ti foams are attractive for orthopaedic applications due to reduced Young's modulus and ability of bone ingrowth. However, poor corrosion behaviour and lack of bioactivity are yet to be overcome. In the present work, highly porous Ti samples were processed by powder metallurgy with space holder technique and bio-functionalized by micro-arc oxidation, resulting in nano/micro structured TiO2 surfaces containing b...
Sponge-derived silica for tissue regeneration: Bioceramics of deep-sea sponge
Dudik, Olesia; Leonor, I. B.; Xavier, Joana R.; Rapp, Hans Tore; Pires, R. A.; Silva, Tiago José Quinteiros Lopes Henriques; Reis, R. L.
The effects of platelet lysate patches on the activity of tendon-derived cells
Almeida, Raquel Carvalho Ferreira Costa; Franco, Albina Ribeiro; Pesqueira, Tamagno; Oliveira, Mariana Braga; Babo, Pedro S.; Leonor, I. B.; Mano, J. F.Platelet-derived biomaterials are widely explored as cost-effective sources of therapeutic factors, holding a strong potential for endogenous regenerative medicine. Particularly for tendon repair, treatment approaches that shift the injury environment are explored to accelerate tendon regeneration. Herein, genipin-crosslinked platelet lysate (PL) patches are proposed for the delivery of human-derived therapeuti...
Silk‐Based antimicrobial polymers as a new platform to design drug‐free materia...
Franco, Albina Ribeiro; Kimmerling, E. P.; Silva, C.; Rodrigues, F.; Leonor, I. B.; Reis, R. L.; Kaplan, D. L.Surgical site infections (SSI) represent a serious health problem that occur after invasive surgery, thus new antimicrobial biomaterials able to prevent SSI are needed. Silks are natural biopolymers with excellent biocompatibility, low immunogenicity and controllable biodegradability. Spider silkbased materials can be bioengineered and functionalized with specific peptides, such as antimicrobial peptides, creat...
A platelet lysate antibacterial bioactive patch for tendon repair
Costa-Almeida, Raquel; Franco, Albina Ribeiro; Leonor, I. B.; Babo, Pedro Miguel Sousa; Pesqueira, Tamagno; Reis, R. L.; Gomes, Manuela E.Platelet lysate (PL) is a class of platelet-rich hemoderivatives produced by cryogenic disruption of platelet concentrates, originating a pool of supra-physiological concentrations of growth factors (GFs) that is being widely explored in the medical field, namely in sports medicine and orthopaedics. In this concern, patch augmentation strategies have been receiving increased attention as the basis for the devel...