6 documents found, page 1 of 1
Genetics- and age-driven neuroimmune and disc changes underscore herniation sus...
Novais, Emanuel J.; Ottone, Olivia K.; Brown, Eric V.; Madhu, Vedavathi; Tran, Victoria A.; Ramteke, Pranay; Dighe, Abhijit S.; Solga, Michael D.There are no appropriate mouse models to study the pathophysiology of spontaneous disc herniations in a wild-type setting. SM/J mice, a poor healer inbred strain, presented a high incidence of age-associated lumbar disc herniations with neurovascular innervations. Transcriptomic comparisons of the SM/J annulus fibrosus with human tissues showed shared pathways related to immune cell activation and inflammation....
Glial-restricted precursors stimulate endogenous cytogenesis and effectively re...
Martins-Macedo, Joana; Araújo, Bruna; Anjo, Sandra I.; Silveira-Rosa, Tiago; Patrício, Patrícia; Alves, Nuno Dinis; Silva, Joana M.; Teixeira, Fábio G.Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and dise...
Astrocyte progenitor transplantation promotes regeneration of bulbospinal respi...
Goulão, Miguel; Ghosh, Biswarup; Urban, Mark W.; Sahu, Malya; Mercogliano, Christina; Charsar, Brittany A.; Komaravolu, Sreeya; Block, Cole G.Stem/progenitor cell transplantation delivery of astrocytes is a potentially powerful strategy for spinal cord injury (SCI). Axon extension into SCI lesions that occur spontaneously or in response to experimental manipulations is often observed along endogenous astrocyte "bridges," suggesting that augmenting this response via astrocyte lineage transplantation can enhance axon regrowth. Given the importance of r...
Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Enshea...
Gomes, Eduardo D.; Mendes, Sofia Silva; Silva, Rita Catarina Assunção Ribeiro; Teixeira, Fábio Gabriel Rodrigues; Pires, Ana O.; Anjo, Sandra I.Patients suffering from spinal cord injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no effective treatments. Therefore, cell therapies have been proposed as a viable alternative to the current treatments used. Adipose tissue-derived stromal cells (ASCs) and olfactory ensheathing cells (OECs) have been used with promising results in different models...
Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels...
Muqeem, Tanziyah; Ghosh, Biswarup; Pinto, Vítor Manuel Silva; Lepore, Angelo C.; Covarrubias, ManuelPresynaptic voltage-gated K+ (Kv) channels in dorsal root ganglion (DRG) neurons are thought to regulate nociceptive synaptic transmission in the spinal dorsal horn. However, the Kv channel subtypes responsible for this critical role have not been identified. The Kv3.4 channel is particularly important because it is robustly expressed in DRG nociceptors, where it regulates action potential (AP) duration. Furthe...
Calcineurin dysregulation underlies spinal cord injury-induced K+ channel dysfu...
Zemel, Benjamin M.; Muqeem, Tanziyah; Brown, Eric V.; Goulão, Miguel; Urban, Mark W.; Tymanskyj, Stephen R.; Lepore, Angelo C.; Covarrubias, ManuelDysfunction of the fast-inactivating Kv3.4 potassium current in dorsal root ganglion (DRG) neurons contributes to the hyperexcitability associated with persistent pain induced by spinal cord injury (SCI). However, the underlying mechanism is not known. In light of our previous work demonstrating modulation ofthe Kv3.4 channel by phosphorylation, we investigatedthe role ofthe phosphatase calcineurin (CaN) using ...