4 documents found, page 1 of 1
Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Ac...
Folquitto,Laís R. S.; Souza,Thiago B. de; Januario,Jaqueline P.; Nascimento,Isadora M.; Brandão,Brenda T. V.; Moreira,Maria E. C.; Horvath,Renato O.Considering the promising antitumor effects of compounds with dual anti-inflammatory and antiproliferative activities, thus benzophenones analogs (2-7) were evaluated on in vivo anti-inflammatory assay and molecular docking analysis. Those with the best molecular docking results were in vitro evaluated on cyclooxygenase (COX) enzymes and tested regarding antiproliferative activity. All derivatives displayed in ...
Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger dif...
Abe,Aneli E.; Oliveira,Carine E. de; Dalboni,Thalita M.; Chagas-Paula,Daniela A.; Rocha,Bruno A.; Oliveira,Rejane B. de; Gasparoto,Thais H.Abstract The tagitinins isolated of Tithonia diversifolia (Hemsl.) A. Gray, Asteraceae, are the most studied sesquiterpene lactones due to their wide spectrum of pharmacologic activities, especially related with nuclear factor-kappa B inhibition. Nevertheless, detailed studies about the mechanism of action of its active compounds are still lacking. Neutrophils perform a fundamental role in the inflammatory resp...
Bioactive compounds in Bidens pilosa L. populations: a key step in the standard...
Cortés-Rojas,Diego F.; Chagas-Paula,Daniela A.; Da Costa,Fernando B.; Souza,Claudia R. F.; Oliveira,Wanderley P.The total flavonoid content (TFC), total polyphenols content (TPC), and in vitro antioxidant activity (AA) of six Bidens pilosa L., Asteraceae, populations harvested from different localities were evaluated in this work. The plants were separated in roots, stems, and leaves/flowers, and the influence of extraction methods was investigated.Areversed-phase high-performance liquid chromatography method (HPLC) was ...
Topical anti-inflammatory activity of yacon leaf extracts
Oliveira,Rejane B.; Chagas-Paula,Daniela A.; Secatto,Adriana; Gasparoto,Thaís H.; Faccioli,Lúcia H.; Campanelli,Ana P.; Costa,Fernando B. DaSmallanthus sonchifolius (Poepp.) H. Rob. , Asteraceae, known as yacon, is an herb that is traditionally used for the treatment of diabetes in folk medicine. However, recent studies have demonstrated that this plant has other interesting properties such as anti-microbial and anti-inflammatory actions. Thus, the purpose of this study was to evaluate the topical anti-inflammatory property of different extracts pr...