3 documents found, page 1 of 1
Up-regulation of Th1-type responses in mucosal leishmaniasis patients
Bacellar, Olívia; Lessa, Hélio; Schriefer, Albert; Machado, Paulo Roberto Lima; Jesus, Amélia Maria Ribeiro de; Dutra, Walderez OrnelasThe cytokine profile produced by peripheral blood mononuclear cells (PBMC) in response to leishmania antigens and the ability of interleukin-10 (IL-10) and transforming growth factor β (TGF-β) to modulate the immune response were evaluated in 21 mucosal leishmaniasis patients. Patients with mucosal disease exhibited increased gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) secretion and decreas...
Cytokine profile and pathology in human leishmaniasis
Jesus, Amélia Maria Ribeiro de; Almeida, Roque Pacheco de; Lessa, Hélio; Bacellar, Olívia; Carvalho Filho, Edgar Marcelino deThe clinical spectrum of leishmaniasis and control of the infection are influenced by the parasite-host relationship. The role of cellular immune responses of the Th1 type in the protection against disease in experimental and human leishmaniasis is well established. In humans, production of IFN-g is associated with the control of infection in children infected by Leishmania chagasi. In visceral leishmaniasis, a...
Decreased in situ expression of interleukin-10 receptor is correlated with the ...
Faria, Daniela Rodrigues de; Gollob, Kenneth John; Barbosa Júnior, José; Schriefer, Nicolaus Albert Borges; Machado, Paulo Roberto Lima; Lessa, HélioHuman infection with Leishmania braziliensis can lead to cutaneous leishmaniasis (CL) or mucosal leishmaniasis (ML). We hypothesize that the intense tissue destruction observed in ML is a consequence of an uncontrolled exacerbated inflammatory immune response, with cytotoxic activity. For the first time, this work identifies the cellular sources of inflammatory and antiinflammatory cytokines, the expression of ...