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MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bil...

Duwe, Lea; Munoz-Garrido, Patricia; Lewinska, Monika; Lafuente-Barquero, Juan; Satriano, Letizia; Høgdall, Dan; Taranta, Andrzej; Nielsen, Boye S.

Background & Aims: Cholangiocarcinoma (CCA) is a heterogeneous and lethal malignancy, the molecular origins of which remain poorly understood. MicroRNAs (miRs) target diverse signalling pathways, functioning as potent epigenetic regulators of transcriptional output. We aimed to characterise miRNome dysregulation in CCA, including its impact on transcriptome homeostasis and cell behaviour. Methods: Small RNA seq...

Date: 2023   |   Origin: Estudo Geral - Universidade de Coimbra
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