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Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as a...
Brito, Alexandra; Pereira, Patrícia M.; Costa, Diana Soares da; Reis, R. L.; Ulijn, Rein V.; Lewis, Rein V.; Pires, R. A.; Pashkuleva, I.We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the cell surface through localized (biocatalytic) self-assembly. We demonstrate that the expression of the cancer asso...
Date: 2020
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Origin: RepositóriUM - Universidade do Minho