3 documents found, page 1 of 1
Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Shift in the Left...
Grilo, Luís F.; Zimmerman, Kip D.; Puppala, Sobha; Chan, Jeannie; Huber, Hillary F.; Li, Ge; Jadhav, Avinash Y. L.; Wang, Benlian; Li, CunAge is a prominent risk factor for cardiometabolic disease, often leading to heart structural and functional changes. However, precise molecular mechanisms underlying cardiac remodeling and dysfunction exclusively resulting from physiological aging remain elusive. Previous research demonstrated age-related functional alterations in baboons, analogous to humans. The goal of this study is to identify early cardia...
Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Re...
Pereira, Susana P.; Diniz, Mariana S.; Tavares, Ludgero C.; Cunha-Oliveira, Teresa; Li, Cun; Cox, Laura A; Nijland, Mark J.; Nathanielsz, Peter W.Intra-uterine growth restriction (IUGR) is a common cause of fetal/neonatal morbidity and mortality and is associated with increased offspring predisposition for cardiovascular disease (CVD) development. Mitochondria are essential organelles in maintaining cardiac function, and thus, fetal cardiac mitochondria could be responsive to the IUGR environment. In this study, we investigated whether in utero fetal car...
Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to m...
Pereira, Susana P.; Tavares, Ludgero C.; Duarte, Ana I.; Baldeiras, Inês; Cunha-Oliveira, Teresa; Martins, João D.; Santos, Maria S.; Maloyan, AlinaPoor maternal nutrition in pregnancy affects fetal development, predisposing offspring to cardiometabolic diseases. The role of mitochondria during fetal development on later-life cardiac dysfunction caused by maternal nutrient reduction (MNR) remains unexplored. We hypothesized that MNR during gestation causes fetal cardiac bioenergetic deficits, compromising cardiac mitochondrial metabolism and reserve capaci...