4 documents found, page 1 of 1
Systemic and vitreous biomarkers : new insights in diabetic retinopathy
Pessoa, Bernardete; Heitor, João; Coelho, Constança; Leander, Magdalena; Menéres, Pedro; Figueira, João; Meireles, Angelina; Beirão, MeloPurpose: Diabetic retinopathy (DR) is a microvascular inflammatory and neurodegenerative disease. The purpose of this study was to analyze the relationship between DR severity and the levels of potential biomarkers in the serum and/or vitreous. Methods: A prospective, consecutive, controlled, observational study was performed between June 2018 and January 2020. Blood and vitreous samples were collected on the d...
IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch
Abreu, Maria; Miranda, Marta; Castro, M; Fernandes, Iolanda; Cabral, Renata; Santos, Ana Helena; Fonseca, Sonia; Rodrigues, João; Leander, MagdalenaThe itch associated with cutaneous T-cell lymphoma (CTCL), including Mycosis Fungoides (MF) and Sézary syndrome (SS), is often severe and poorly responsive to treatment with antihistamines. Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated the role of IL-31 and IL-8 in CTCL, concerning disease severity and associated itch. Serum samples of 27 patients wi...
Metabolic control of T cell immune response through glycans in inflammatory bow...
Dias, Ana M.; Correia, Alexandra; Pereira, Márcia S.; Almeida, Catarina R.; Alves, Inês; Pinto, Vanda; Catarino, Telmo A.; Mendes, NunoMucosal T lymphocytes from patients with ulcerative colitis (UC) were previously shown to display a deficiency in branched N-glycosylation associated with disease severity. However, whether this glycosylation pathway shapes the course of the T cell response constituting a targeted-specific mechanism in UC remains largely unknown. In this study, we demonstrated that metabolic supplementation of ex vivo mucosal T...
Circulating endothelial cells in patients with venous thromboembolism and myelo...
Torres, Cláudia; Fonseca, Ana Mafalda; Leander, Magdalena; Matos, Rui; Morais, Sara; Campos, Manuel; Lima, MargaridaBackground: Circulating endothelial cells (CEC) may be a biomarker of vascular injury and pro-thrombotic tendency, while circulating endothelial progenitor cells (CEP) may be an indicator for angiogenesis and vascular remodelling. However, there is not a universally accepted standardized protocol to identify and quantify these cells and its clinical relevancy remains to be established. Objectives: To quantify C...