4 documents found, page 1 of 1
Microexon gene transcriptional profiles and evolution provide insights into blo...
Li, Xiao Hong; DeMarco, Ricardo; Neves, Leandro Xavier; James, Sally R.; Newling, Katherine; Ashton, Peter D.; Cao, Jian Ping; Wilson, R. AlanAdult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonic...
Do schistosome vaccine trials in mice have an intrinsic flaw that generates spu...
Wilson, R. Alan; Li, Xiao Hong; Borges, William de CastroThe laboratory mouse has been widely used to test the efficacy of schistosome vaccines and a long list of candidates has emerged from this work, many of them abundant internal proteins. These antigens do not have an additive effect when co-administered, or delivered as SWAP homogenate, a quarter of which comprises multiple candidates; the observed protection has an apparent ceiling of 40–50 %. We contend that t...
The schistosome eesophageal gland : initiator of blood processing.
Li, Xiao Hong; Borges, William de Castro; Manuel, Sophie J. Parker; Vance, Gillian M.; DeMarco, Ricardo; Neves, Leandro Xavier; Evans, Garet J. O.Background: Although the ultrastructure of the schistosome esophageal gland was described .35 years ago, its role in the processing of ingested blood has never been established. The current study was prompted by our identification of MEG-4.1 expression in the gland and the observation of erythrocyte uncoating in the posterior esophagus. Methodology/Principal Findings: The salient feature of the posterior esopha...
Schistosome feeding and regurgitation.
Skelly, Patrick J.; Da'dara, Akram A.; Li, Xiao Hong; Borges, William de Castro; Wilson, R. AlanSchistosomes are parasitic flatworms that infect .200 million people worldwide, causing the chronic, debilitating disease schistosomiasis. Unusual among parasitic helminths, the long-lived adult worms, continuously bathed in blood, take up nutrients directly across the body surface and also by ingestion of blood into the gut. Recent proteomic analyses of the body surface revealed the presence of hydrolytic enzy...