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Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysi...

Robinson, L; Roccaldo, R; Rodrigues, D; Rodriguez Perez, MdC; Rodríguez Villamizar, LA; Rodríguez, AY; Roggenbuck, U; Rohloff, P; Rohner, F

Background: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods: We used data from 3663 population-based studies with 222 million participants that...


How prices and income influence global patterns in saturated fat intake by age,...

Ahles, A; Muhammad, A; Yenerall, JN; Reedy, J; Shi, P; Zhang, J; Cudhea, F; Erndt-Marino, J; Miller, V; Mozaffarian, D; Abbott, P; Abdollahi, M

Objective When considering proposals to improve diets, it is important to understand how factors like price and income can affect saturated fat (SF) intake and demand. In this study, we examine and estimate the influence of price and income on intake across 160 countries, by age and sex, and derive sensitivity measures (price elasticities) that vary by age, sex and world region. Design We econometrically estima...


Children's and adolescents' rising animal-source food intakes in 1990-2018 were...

Miller, V; Webb, P; Cudhea, F; Zhang, J; Reedy, J; Shi, P; Erndt Marino, J; Coates, J; Micha, R; Mozaffarian, D; Bas, M; Ali, JH; Abumweis, S

Animal-source foods (ASF) provide nutrition for children and adolescents physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional and national ASF intakes between 1990 and 2018 by age group across 185 countries, representing 93% of the worlds child population. Mean ASF intake was 1.9 servings per day, representing 16% of...


Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

Casco, N; Jorge, AL; Palmero, DJ; Alffenaar, JW; Fox, GJ; Ezz, W; Cho, JG; Denholm, J; Skrahina, A; Solodovnikova, V; Arbex, MA; Alves, T; Rabahi, MF

Background Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end...


Incident type 2 diabetes attributable to suboptimal diet in 184 countries

OHearn, M; Lara Castor, L; Cudhea, F; Miller, V; Reedy, J; Shi, P; Zhang, J; Wong, JB; Economos, CD; Micha, R; Mozaffarian, D; Bas, M; Ali, JH

The global burden of diet-attributable type 2 diabetes (T2D) is not well established. This risk assessment model estimated T2D incidence among adults attributable to direct and body weight-mediated effects of 11 dietary factors in 184 countries in 1990 and 2018. In 2018, suboptimal intake of these dietary factors was estimated to be attributable to 14.1 million (95% uncertainty interval (UI), 13.814.4 million) ...


Author Correction: Global dietary quality in 185 countries from 1990 to 2018 sh...

Miller, V; Webb, P; Cudhea, F; Shi, P; Zhang, J; Reedy, J; Erndt Marino, J; Coates, J; Mozaffarian, D; Bas, M; Ali, JH; Abumweis, S; Krishnan, A

[No abstract available]


Global Chronic Total Occlusion Crossing Algorithm

Wu, EB; Brilakis, ES; Mashayekhi, K; Tsuchikane, E; Alaswad, K; Araya, M; Avran, A; Azzalini, L; Babunashvili, AM; Bayani, B; Behnes, M; Bhindi, R

The authors developed a global chronic total occlusion crossing algorithm following 10 steps: 1) dual angiography; 2) careful angiographic review focusing on proximal cap morphology, occlusion segment, distal vessel quality, and collateral circulation; 3) approaching proximal cap ambiguity using intravascular ultrasound, retrograde, and move-the-cap techniques; 4) approaching poor distal vessel quality using th...

Date: 2021   |   Origin: Lusíadas Saúde

Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis

Cardoso, A; Martins, AC; Maceiras, AR; Liu, W; Castro, I; Castro, AG; Bandeira, A; Di Santo, JP; Cumano, A; Li, Y; Vieira, P; Saraiva, M

In emergency myelopoiesis (EM), expansion of the myeloid progenitor compartment and increased myeloid cell production are observed and often mediated by the pro-inflammatory cytokine interferon gamma (IFN-γ). Interleukin-10 (IL-10) inhibits IFN-γ secretion, but paradoxically, its therapeutic administration to humans causes hematologic changes similar to those observed in EM. In this work, we use different in vi...


Height and body-mass index trajectories of school-aged children and adolescents...

Horimoto, AR; Hormiga, CM; Horta, BL; Houti, L; Howitt, C; Htay, TT; Htet, AS; Htike, MMT; Hu, Y; Huerta, JM; Huhtaniemi, IT; Huidumac Petrescu, C

Background: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods: For this pooled analysis, we used a database of cardiometabolic risk factors colla...


Hierarchical structured and programmed vehicles deliver drugs locally to inflam...

Li, W; Li, Y; Liu, Z; Kerdsakundee, N; Zhang, M; Zhang, F; Liu, X; Bauleth-Ramos, T; Lian, W; Mäkilä, E; Kemell, M; Ding, Y; Sarmento, B

Orally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehi...


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