16 documents found, page 1 of 2

Development of bioabsorbable polylactide membrane with controllable hydrophilic...

Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the h...

pH sensitive mesoporous nanohybrids with charge-reversal properties for antican...

The surface/interface state of nanomaterials plays a key role on their biomedical applications. Nanotechnology offers a versatile means to develop nanoparticles with well-defined architecture. In this study, mesoporous silica nanoparticles were firstly loaded with an anticancer drug (doxorubicin, DOX), which were then decorated with a cationic oligomer (low molecular weight polyethyleneimine, LPEI) to acquire a...

Biodegradable polymer nanogels for drug/nucleic acid delivery

Nonionic surfactant-stabilized raspberry-like polymer/silica nanoparticles late...

Raspberry-like P(St-BA)/SiO2 nanoparticle latexes were prepared via miniemulsion polymerization of styrene (St) and butyl acrylate (BA) in the presence of 20 nm glycerol-modified SiO2 sol as a Pick ering emulsifier and octaphenyl polyoxyethylene (CA-897) as a nonionic surfactant, using 2,2-azobis (isobutyronitrile) (AIBN) as an initiator. 2-(Methacryloyl) ethyltrimethylammonium chloride (MTC) was introduced to ...

Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) na...

The clinical application of doxorubicin (DOX), like other anticancer drugs, is limited by insufficient cellular uptake and the numerous drug resistance mechanisms existing in cells. The development of smart nanomaterials capable of carrying the drugs into the cells and of releasing them under the control of the microenvironment is an interesting approach that may increase the success of the anticancer drugs curre...

Antitumor efficacy of doxorubicin-loaded laponite/alginate hybrid hydrogels

Degradable hybrid hydrogels with improved stability are prepared by incorporating nanodisks of biocompatible laponite (LP) in alginate (AG) hydrogels using Ca2+ as a crosslinker. The Dox‐loaded hybrid hydrogels give a controlled Dox release at physiological environment in a sustained manner. Under conditions that mimic the tumor environment, both the sustainability in the Dox release (up to 17 d) and the releas...

pH-sensitive Laponite®/doxorubicin/alginate nanohybrids with improved anticance...

The efficacy of the anticancer drug doxorubicin (Dox) is limited by an insufficient cellular uptake and drug resistance, which is partially due to ion trapping in acidic environments such as the extracellular environment of solid tumors and the interior of endolysosome vesicles. Herein, we describe the preparation and in vitro evaluation of a new type of nanohybrid for anticancer drug delivery which is capable ...

Dendrimer-assisted formation of fluorescent nanogels for drug delivery and intr...

Although, in general, nanogels present a good biocompatibility and are able to mimic biological tissues, their unstability and uncontrollable release properties still limit their biomedical applications. In this study, a simple approach was used to develop dual-cross-linked dendrimer/alginate nanogels (AG/G5), using CaCl2 as cross-linker and amine-terminated generation 5 dendrimer (G5) as a cocrosslinker, throu...

Amphiphilic polymer-mediated formation of laponite-based nanohybrids with robus...

The development of pH-sensitive drug delivery nanosystems that present a low drug release at the physiological pH and are able to increase the extent of the release at a lower pH value (like those existent in the interstitial space of solid tumors (pH 6.5) and in the intracellular endolysosomal compartments (pH 5.0)) is very important for an efficient and safe cancer therapy. Laponite (LP) is a synthetic silica...

Antitumor efficacy of doxorubicin encapsulated within PEGylated poly(amidoamine...

We report here a general approach to using poly(amidoamine) (PAMAM) dendrimers modified with polyethylene glycol (PEG) as a platform to encapsulate an anticancer drug doxorubicin (DOX) for in vitro cancer therapy applications. In this approach, PEGylated PAMAM dendrimers were synthesized by conjugating monomethoxypolyethylene glycol with carboxylic acid end group (mPEG-COOH) onto the surface of generation 5 ami...