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Hierarchical structured and programmed vehicles deliver drugs locally to inflam...
Li, W; Li, Y; Liu, Z; Kerdsakundee, N; Zhang, M; Zhang, F; Liu, X; Bauleth-Ramos, T; Lian, W; Mäkilä, E; Kemell, M; Ding, Y; Sarmento, BOrally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehi...
Date: 2018
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Origin: Repositório Aberto da Universidade do Porto