2 documents found, page 1 of 1
Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy...
Pinto, CJG; Ávila-Gálvez, MÁ; Lian, Y; Moura-Alves, P; Santos, CNThe Aryl Hydrocarbon Receptor (AHR) is a ligand-dependent transcription factor able to control complex transcriptional processes in several cell types, which has been correlated with various diseases, including inflammatory bowel diseases (IBD). Numerous studies have described different compounds as ligands of this receptor, like xenobiotics, natural compounds, and several host-derived metabolites. Dietary (pol...
The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Diffe...
Flegel, J; Shaaban, S; Jia, ZJ; Schulte, B; Lian, Y; Krzyzanowski, A; Metz, M; Schneidewind, T; Wesseler, F; Flegel, A; Reich, A; Brause, A; Xue, GIdentification and analysis of small molecule bioactivity in target-agnostic cellular assays and monitoring changes in phenotype followed by identification of the biological target are a powerful approach for the identification of novel bioactive chemical matter in particular when the monitored phenotype is disease-related and physiologically relevant. Profiling methods that enable the unbiased analysis of comp...