2 documents found, page 1 of 1
Antheraea pernyi silk nanofibrils with inherent RGD motifs accelerate diabetic ...
Duan, Lian; Liu, Ga; Liao, Fuying; Xie, Chunyu; Shi, Jiahao; Yang, Xiao; Zheng, Fan; Reis, R. L.; Kundu, Subhas C; Xiao, BoThe chronic inflammation and matrix metalloprotease (MMP)-induced tissue degradation significantly disrupt re-epithelization and delay the healing process of diabetic wounds. To address these issues, we produced nanofibrils from Antheraea pernyi (Ap) silk fibers via a facile and green treatment of swelling and shearing. The integrin receptors on the cytomembrane could specifically bind to the Ap nanofibrils (Ap...
Injectable dual-network hydrogel for phototherapy and immunomodulation in the t...
Bao, Shengfei; Jiang, Aodi; Peng, Li; Liao, Fuying; Liu, Ga; Chen, Li; Zhou, Peng; Zhu, Zhen; Reis, R. L.; Kundu, Subhas C; Duan, Lian; Xiao, BoContinuous invasion and infection of drug-resistant bacteria leads to chronic inflammation and ulcers in skin wounds, which hinders wound healing and even results in sepsis. Here, we constructed a multifunctional injectable hydrogel (GA/PIOP/SF) that was composed of a synthesized porous ionic organic polymer (PIOP) with photothermal and photodynamic therapy (PDT/PTT) capacities to kill bacteria, a bioactive sma...