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Serological screening in a large-scale municipal survey in Cascais, Portugal, d...

Funding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by Fundação para a Ciência e Tecnologia (FCT) through funds to GHTM – UID/04413/2020 and LA-REAL – LA/P/0117/2020. The study received the contribution from the EuCARE Project funded by the European Union’s Horizon Europe Research and Innovation Prog...

Increasing prevalence of HIV-1 transmitted drug resistance in Portugal

Introduction: Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug resistance (ADR). Objective: To study the trends of TDR and ADR in patients followed up in Portuguese hospitals between 2001 and 2017. Methods: In total, 11,911 p...

Molecular epidemiology of HIV-1 infected migrants followed up in Portugal

Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as ...

A prospect on the use of antiviral drugs to control local outbreaks of COVID-19

Background: Current outbreaks of COVID-19 are threatening the health care systems of several countries around the world. Control measures, based on isolation, contact tracing, and quarantine, can decrease and delay the burden of the ongoing epidemic. With respect to the ongoing COVID-19 epidemic, recent modeling work shows that these interventions may be inadequate to control local outbreaks, even when perfect ...

Drivers of HIV-1 transmission

BACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. METHODS: Demographic, clinical and genomic data were collected ...

Zika genomics urgently need standardized and curated reference sequences

Epidemic dispersion of HIV and HCV in a population of co-infected Romanian inje...

Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to characterize and compare transmission dynamics of the...

PhyloGeoTool

Funding Information: The authors thank the EuResist Network (www.euresist.org) for providing data and the reviewers for their insightful comments which improved both the manuscript and PhyloGeoTool software. Funding Information: This work was supported by EucoHIV (www.eucohiv.org). K.T. is funded as a Postdoctoral Researcher by the Research Foundation \u2013 Flanders (FWO). P.L. is funded by a doctoral grant of...