253 documents found, page 1 of 26
Liposomal formulations for efficient delivery of a novel, highly potent pyrimid...
Teixeira, Sofia; Ferreira, Débora Carina Gonçalves Abreu; Rodrigues, Ana Rita Oliveira; Rodrigues, L. R.; Castanheira, Elisabete M. S.Background/Objectives: Cancer is one of the deadliest diseases worldwide. Despite the existing treatments, the adverse side effects and the increasing drug resistance to the current therapies lead to a reduced quality of life for patients and poor prognosis. The pyrimido[5,4-d]pyrimidine compound (PP) was identified as a promising new anticancer drug due to its potent activity against colorectal and triple-nega...
Multifunctional magneto-plasmonic lipogel based on peptide hydrogel for applica...
Gomes, Valéria; Veloso, Sérgio R. S.; Carvalho, André; Hilliou, L.; Coutinho, Paulo J. G.; Moura, C.; Martins, J. A. R.; Castanheira, Elisabete M. S.Supramolecular hydrogels, particularly low-molecular-weight peptide hydrogels, are promising drug delivery systems due to their ability to change the solubility, targeting, metabolism and toxicity of drugs. Magneto-plasmonic liposomes, in addition to being remotely controllable with the application of an external magnetic field, also increase the efficiency of encapsulated drug release through thermal stimulati...
Development of eugenol derivatives with 5-LOX inhibitory activity
Filho, José L. Pereira; Pereira, Renato B.; Vieira, Tatiana F.; Sousa, Sérgio F.; Coelho, José Ricardo Alves; Pinto, Nuno F. S.; Coelho, Catarina M. M.Eugenol (4-allyl-2-methoxyphenol), is the major chemical constituent in the essential oil of numerous plant species. Several biological properties have been described for this molecule, including modulation of enzymatic targets relevant for the inflammatory response, such as 5-lipoxygenase (5-LOX). As so, there is interest in expanding the chemical space of this molecule to develop new molecules to be used in i...
Hydrazides as powerful tools in medicinal chemistry: synthesis, reactivity, and...
Teixeira, Sofia; Castanheira, Elisabete M. S.; Carvalho, M. AliceThe increase in drug resistance and the high toxicity of current drugs have inspired the scientific community to develop new drugs for various diseases. Hydrazides have become an attractive functional group to easily obtain a plethora of novel compounds with a broad range of biological activities. This review, which contains studies in the literature from the previous five years, focuses on the synthesis method...
Evaluation of the photothermal performance of the Prussian blue/hydroxyapatite ...
Costa, Achilley Nahid Barros; Serra, Josilene Lima; da Luz Rodrigues, Israel; Mendonça, Leonardo Tadeu Boaes; Pereira, GoretiIn this study, Prussian Blue (PB) and hydroxyapatite (HAp) composites were developed and synthesized in situ within an alginate gel, resulting in materials with excellent photothermal conversion efficiency. Structural information and morphology of the composites were obtained by using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), UV–vis absorption spectroscopy, and Scanning Electron M...
Self-assembly pathway influence on Dehydropeptide-based gel properties and drug...
Veloso, Sérgio R S; Vijayakanth, Thangavel; Shankar, Sudha; Fridman, Natalia; Rencus-Lazar, Sigal; Hilliou, L.; Rodrigues, Pedro V.; Moura, C.Low-molecular-weight peptide-based hydrogels formed through self-assembly have emerged as promising candidates for biomedical applications. While the self-assembly process is known to affect the network morphology, its impact on mechanical properties and drug delivery remains poorly understood. In this work, it is explored how different gelation conditions influence the morphology, properties, and drug release ...
New cation sensors based on eugenol-derived azo dyes
Coelho, José R. A.; Pacheco, Ana Rita Faria; Domingues, Diogo C.; Rodrigues, Ana Rita Oliveira; Temitope, Akani A.; Coutinho, Paulo J. G.Eugenol-based azo dyes illustrate how bio-sourced compounds like eugenol can be transformed through synthetic processes into functional and colorful compounds. The main purpose of the present work was to develop new responsive colorimetric sensors for metal cations based on eugenol-derived azo compounds. The incorporation of the azo group into the eugenol framework allows for strong electronic interactions with...
Albumin/Hyaluronic acid nanoparticle-laden contact lenses for the ocular delive...
Senra, Sara F. M.; Veloso, Sérgio Rafael Silva; Lira, Madalena; Castanheira, Elisabete M. S.Nanoparticle-laden contact lenses are a formidable strategy for ocular drug delivery. However, incorporating nanoparticles to achieve sustained drug release without affecting the contact lenses' properties remains a challenging task. In this work, daily and monthly replacement silicone-hydrogel contact lenses laden with bovine serum albumin/hyaluronic acid (BSA/HA) nanoparticles are presented. These nanoparticl...
Albumin/Hyaluronic acid gel nanoparticles loaded with a pyrimidine-based drug f...
Teixeira, Sofia; Ferreira, Débora Carina Gonçalves Abreu; Rodrigues, L. R.; Carvalho, M. Alice; Castanheira, Elisabete M. S.A pyrimidine-based compound (PP) was recently found to be a promising anticancer agent for colorectal and breast cancers. However, this compound exhibited low selectivity and poor water solubility. To address these challenges, albumin gel nanoparticles were used, where the gel matrix is formed by cross-linking of BSA molecules, allowing for a high concentration of this hydrophobic drug to be carried with no cyt...
Chitosan/alginate polyelectrolyte magnetic gel nanoarchitectonics with tunable ...
Veloso, Sérgio Rafael Silva; Vázquez-González, Margarita; Ribeiro, Mariana O.; Hilliou, L.; Amorim, Carlos O.; Amaral, Vítor S.Chitosan-based hydrogels hold promise as drug delivery systems for cancer therapy, but the poor mechanical properties often limit the biological application, requiring chemical cross-linking to improve sustained drug release. Besides, the addition of stimulus-responsiveness to chitosan requires chemical modifications that can further affect the gel properties. To overcome these challenges, in this work, a novel...