4 documents found, page 1 of 1
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation...
Lemos, Henrique Paula; Grespan, Renata; Manfredo Vieira, Silvio; Cunha, Thiago Mattar; Verri, Waldiceu A.; Fernandes, Karla S.; Souto, Fabrício OliveiraIL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN γ production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-...
Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
Colón, David F.; Wanderley, Carlos W.; Franchin, Marcelo; Silva, Camila M.; Hiroki, Carlos H.; Castanheira, Fernanda V. S.; Donate, Paula B.Background: Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. Methods: Infant (2 weeks old) and adult (6 weeks old) mice were submitted to sepsis by intraperitoneal (i.p.) injection of bacteria suspension or lipopolysaccharide (LPS). Neutrophil infiltration, bacteremia, ...
Nitric oxide-induced regulatory T cells inhibit Th 17 but not Th1 cell differen...
Liew, Foo Y.
IL-33 attenuates EAE by suppressing IL-17 and IFN-y production and inducing alt...
Liew, Foo Y.