4 documents found, page 1 of 1
A functional polymorphism in IL-36β modulates macrophage antifungal effector fu...
Gonçalves, Samuel M.; Leite, L.; de Vasconcelos, P.; Pereira, I.; Dewi, I. M. W.; Mercier, T.; Aerts, R.; Ligeiro, D.; Mendes, F.; Freitas, F.Background: Genetic predisposition plays a major role in the development of invasive pulmonary aspergillosis (IPA). The risk and course of IPA vary significantly among patients, yet continuously new genetic mechanisms that influence individual antifungal immune responses are being discovered. While genetic variability in interleukin (IL)-1 family cytokines is recognized as an important cause of disease suscepti...
Long-term immune reconstitution of naive and memory t cell pools after haploide...
Azevedo, R. I.; Soares, M. V.; Albuquerque, A. S.; Tendeiro, R.; Soares, R. S.; Martins, M.; Ligeiro, D.; Victorino, R. M.; Lacerda, J. F.; Sousa, A. E.Haploidentical hematopoietic stem cell transplantation (HSCT) constitutes an important alternative for patients lacking a human leukocyte antigen (HLA)-matched donor. Although the use of haploidentical donors is increasingly common, the long-term impact of generating a donor-derived immune system in the context of an HLA-mismatched thymic environment remains poorly characterized. We performed an in-depth assess...
Involvement of the Ig heavy chain locus in autoantibody reactivity in Portugues...
Rolim, M. I. H.; Boavida, J. M.; Duarte, R.; Pina, R.; Valadas, C.; Pratas, S.; Carvalho, R.; Costa, J.; Ligeiro, D.; Sancho, M. R.; Catarino, M. M.
Espondilite Anquilosante e sua Base Genética
Pimentel dos Santos, F. M.; Ligeiro, D.; Mourão, A. F.; Branco, Jaime Cunha; Bastos, Estela; Trindade, Henrique; Chaves, Raquel; Guedes-Pinto, Henrique