11 documents found, page 1 of 2
Intrathecal injection of the secretome from ALS motor neurons regulated for miR...
Barbosa, Marta; Santos, Marta; de Sousa, Nídia; Silva, Sara Carina Duarte; Vaz, Ana Rita; Salgado, A. J.; Brites, DoraAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy. We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) and established its implication in mSOD1 MN degeneration and glial cell activation. When anti-miR-124-treated mSOD1 MN (preconditioned) secretome was incubated in spinal cord organotyp...
One Year of COVID-19 in Pregnancy: A National Wide Collaborative Study
Borges Charepe, Nadia; Queirós, Alexandra; Alves, Maria José; Serrano, Fátima; Ferreira, Catarina; Gamito, Mariana; Smet, Carolina; Silva, VanessaIntroduction: Even though the risk of COVID-19 in pregnancy may be increased, large-scale studies are needed to better understand the impact of the infection in this population. The aim of this study is to describe obstetric complications and the rate of vertical transmission in pregnant women with SARS-CoV-2 infection.Material and Methods: Detected cases of SARS-CoV-2 infection in pregnancy were registered in ...
Viral proteins to improve the detection of secondary bacterial infections (SBI)...
Santos, Sílvio Roberto Branco; Barbosa, Marta; Pires, Diana Priscila Penso; Melo, Luís Daniel Rodrigues; Vieira, Ana Raquel; Faustino, AlbertaBacteriophages (phages) are characterized for their high specificity being able to discriminate their host up to the strain level. This feature is largely dependent on specific structural proteins encoded on the phages genomes. These proteins recognize specific receptors on the bacterial cell surface and are known as phage receptor binding proteins (RBP). The ability to specifically recognize and bind to certai...
Evaluation of promising miRNA modulation in neural cells and derived secretomes...
Barbosa, MartaAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron (MN) loss, astrocyte/microglia dysfunction and with lack of effective treatments. Dysregulation of inflammatory-miRNAs in cells and their dissemination via secretome (as free species and encapsulated in sEVs) contribute to ALS pathophysiology and their regulation may constitute a therapeutic approach. Thus, th...
Recovery of depleted miR-146a in ALS cortical astrocytes reverts cell aberranci...
Barbosa, Marta; Gomes, Cátia; Sequeira, Catarina; Gonçalves-Ribeiro, Joana; Pina, Carolina Campos; Carvalho, Luís A.; Moreira, Rui; Vaz, Sandra H.Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular expression pattern and release toxic factors that contribute to neurodegeneration and microglial activation. We and others identified a dysregulated inflammatory miRNA profile in ALS patients and in mice models suggesting that they represent potential targets for therapeutic intervention. Such cellular miRNAs are known to be relea...
Automatic Classification and Segmentation of Low-Grade Gliomas in Magnetic Reso...
Barbosa, Marta; Moreira, Pedro; Ribeiro, Rogério; Coelho, LuisIn this article a new methodology is proposed to tackle the problem of automatic segmentation of low-grade gliomas. The possibility of knowing the limits of this type of tumor is crucial for effectively characterizing the neoplasm, enabling, in certain cases, to obtain useful information about how to treat the patient in a more effective way. Using a database of magnetic resonance images, containing several occ...
Sina social cigana. História, comunidades, representações e instituições
Silva, Manuel Carlos; Silva, Susana; Pinto, Maria Goreti; Sobral, José Manuel; Ramos, Mariana; Barbosa, Marta; Silva, Isabel; Cid, Carla SofiaEste livro, tendo por base alguns resultados de um projecto de investigação, retrata as condições de vida e trabalho de famílias e comunidades ciganas no distrito de Braga, assim como as suas situações de privação nos acampamentos e bairros sociais, níveis de escolaridade, modos de vida, relações de vizinhança e conflitos intra e interétnicos, rituais e crenças desde o casamento à morte e subsequente luto. Por ...
Ecotoxicological evaluation of wastewater in a municipal WWTP in Lisbon area (P...
Mendonça, E.; Picado, Ana; Paixão, Susana M.; Silva, Luís; Barbosa, Marta; Cunha, Maria AnaWastewater management has a central role in sustainable development, and, in this context, an integrated management of wastewater treatment plants (WWTP) can be important. WWTP discharge complex effluents and for a new strategy in environmental protection ecotoxicological evaluation should complement the usual chemical evaluation. The EU project WW4Environment was set up for a WWTP located in Lisbon area and di...
Comportamento do tronco na fase inicial da sequência de movimento de sentado pa...
Barbosa, MartaAs alterações do controlo postural do tronco observadas em indivíduos pós acidente vascular encefálico (AVE) podem traduzir-se em dificuldades na realização da sequência de movimento de sentado para de pé (STS). Desta forma, o presente estudo teve como objetivo descrever o comportamento do tronco, durante a primeira fase do STS, em cinco indivíduos pós-AVE, em fase aguda. Para tal, os indivíduos foram avaliados...
Ecotoxicological evaluation of wastewater in a municipal WWTP in Lisbon area (P...
Mendonça, E.; Picado, Ana; Paixão, Susana M.; Silva, Luís; Barbosa, Marta; Cunha, Maria AnaWastewater management has a central role in sustainable development, and, in this context, an integrated management of wastewater treatment plants (WWTP) can be important. WWTP discharge complex effluents and for a new strategy in environmental protection ecotoxicological evaluation should complement the usual chemical evaluation. The EU project WW4Environment was set up for a WWTP located in Lisbon area and di...