9 documents found, page 1 of 1
Protective Effect of cashew gum (Anacardium occidentale L.) on 5-Fluorouracil-i...
Miranda, João Antônio Leal de; Barreto, João Erivan Façanha; Martins, Dainesy Santos; Pimentel, Paulo Vitor de Souza; Costa, Deiziane Viana da SilvaIntestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the e ect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into...
Determinação de alterações na expressão gênica, fenótipos comportamentais e pad...
Lima, Camila Nayane de CarvalhoTemperament can be considered the basis of humor, behavior and personality, they have strong biological basis, early development of the individual. Evidences suggests that temperament and personality traits predispose to the mood disorders. Because of this, it is important to identify biological factors associated with various temperament characteristics, such as differences in gene expression and neurochemical...
Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- an...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Chaves Filho, Adriano José Maia; Lima, Camila Nayane de CarvalhoEarly-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic...
Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in m...
Oliveira, Aline de Albuquerque; Linhares, Maria Isabel; Chaves Filho, Adriano José Maia; Rios, Emiliano Ricardo VasconcelosThis study aimed to investigate the in vitro antioxidant activity of the novel anticonvulsant levetiracetam and benzodiazepine clonazepam. To do this, the mice brain homogenates were incubated with levetiracetam (50, 100 or 200 g/ml) or clonazepam (50, 100 or 200 g/ml), and then, submitted to heating at 37°C for 1 h. Ascorbic acid (vitamin C, 200 g/ml) was used as reference antioxidant drug. The markers of o...
Recurso audiovisual para promoção do apego entre mãe HIV soropositiva e seu filho
Lima, Camila Nayane de Carvalho; Barbosa, Régia Christina Moura; Pinheiro, Ana Karina Bezerra; Pinto, Maria Liduína FreitasThe study aimed at evaluating the effects of the educational video use to promote the attachment between HIV positive mother and her son after six months of contact between them.This is an exploratory-descriptive study with a qualitative approach. Data was collected through semi-structured interviews. The sampling was intentional. The plan of analysis consisted of the following steps: the constitution of the co...
Potencial convulsivante de carbapenêmicos em diferentes modelos experimentais d...
Lima, Camila Nayane de CarvalhoEpilepsy is the most common neurological disorder, affecting 50 million people worldwide, 40 million of them in developed countries. People of all races, genders, socioeconomic conditions and regions are affected. The pilocarpine (P400) is a cholinergic agonist characterized by inducing seizures evolving to status epilepticus, similar to human temporal lobe epilepsy. The pentylenetetrazole (PTZ) is a GABA antag...
The effects of the brazilian ant Dinoponera quadriceps venom on chemically indu...
Lopes, Kamila Soares; Rios, Emiliano Ricardo Vasconcelos; Lima, Camila Nayane de Carvalho; Linhares, Maria Isabel; Torres, Alba Fabíola CostaArthropod venoms are potential sources of neuroactive substances, providing new tools for the design of drugs. The aim of this study was to evaluate the effects of Dinoponera quadriceps venom (DqV) on seizure models in mice induced by pentylenetetrazole (PTZ), pilocarpine, and strychnine. In the PTZ model, intraperitoneal treatment with DqV (0.5 mg/kg) increased the time until the first seizure and the percenta...
Recurso audiovisual para promoção do apego entre mãe HIV soropositiva e seu filho
Lima, Camila Nayane de Carvalho; Barbosa, Régia Christina Moura; Pinheiro, Ana Karina Bezerra; Pinto, Maria Liduína FreitasO estudo objetivou avaliar os efeitos da utilização do vídeo educativo para promoção do apego entre mãe soropositiva para o HIV e seu filho após seis meses de interação entre ambos. Trata-se de um estudo descritivo-exploratório com abordagem qualitativa. Os dados foram coletados através de entrevista semiestruturada. A amostragem foi intencional. O plano de análise seguiu os seguintes passos: constituição do co...
Action audio-visual for the promotion of between mother attachment seropositivi...
Lima, Camila Nayane de Carvalho; Barbosa, Régia Christina Moura; Pinheiro, Ana Karina Bezerra; Pinto, Maria Liduína FreitasThe study aimed at evaluating the effects of the educational video use to promote the attachment between HIV positive mother and her son after six months of contact between them.This is an exploratory-descriptive study with a qualitative approach. Data was collected through semi-structured interviews. The sampling was intentional. The plan of analysis consisted of the following steps: the constitution of the co...