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Clostridium difficile toxin A attenuates Wnt/B-Catenin signaling in intestinal ...
Lima, Bruno Bezerra; Fonseca, Bárbara Faria; Amado, Nathália da Graça; Lima, Débora Moreira; Ribeiro, Ronaldo Albuquerque; Abreu, José GarciaClostridium difficile toxins A and B (TcdA and TcdB) are homologous glycosyltransferases that inhibit a group of small GTPases within host cells, but several mechanisms underlying their pathogenic activity remain unclear. In this study, we evaluated the effects of TcdA on the Wnt/ -catenin pathway, the major driving force behind the proliferation of epithelial cells in colonic crypts. IEC-6 and RKO cells stimul...
Date: 2015
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Origin: Oasisbr