3 documents found, page 1 of 1
(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerizat...
Magalhães, Hemerson I. F.; Wilke, Diego V.; Bezerra, Daniel P.; Cavalcanti, Bruno C.; Rotta, Rodrigo; Lima, Dênis P. de; Beatriz, Adilson(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone (PHT) is a known cytotoxic compound belonging to the phenstatin family. However, the exact mechanism of action of PHT-induced cell death remains to be determined. The aim of this study was to investigate the mechanisms underlying PHT-induced cytotoxicity. We found that PHT displayed potent cytotoxicity in different tumor cell lines, showing IC50 values in the n...
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Mahmoud, Talal Suleiman [UNESP]; Marques, Maria Rita; Pessoa, Cláudia do Ó; Lotufo, Leticia V. C.; Magalhães, Hemerson I. F.; Moraes, Manoel O. deSubmitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:57:49Z No. of bitstreams: 1 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5); Made available in DSpace on 2013-08-22T18:57:49Z (GMT). No. of bitstreams: 1 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5) Previous issue date: 2011-06-01; Made availabl...
Total synthesis and allelopathic activity of cytosporones A-C
Zamberlam, Charles E. M.; Meza, Alisson; Leite, Carla Braga; Marques, Maria Rita; Lima, Dênis P. de; Beatriz, AdilsonA busca por herbicidas eficientes e ambientalmente corretos tem sido foco de numerosos estudos sobre a síntese de compostos isolados de fontes naturais. Citosporonas, as quais são lipídeos fenólicos isolados de fungos, apresentam notáveis propriedades biológicas. Este artigo relata a preparação das citosporonas A, B e C, através de uma rota sintética curta e com excelentes rendimentos. Os compostos sintetizados...