10 documents found, page 1 of 1

Insecticidal Effect of Extracts from Native Plants of Mato Grosso do Sul State ...

Made available in DSpace on 2015-05-15T13:30:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2010Bitstream added on 2015-05-15T13:56:34Z : No. of bitstreams: 1 ISSN1809-8460-2010-05-01-01-05.pdf: 62663 bytes, checksum: c59822cb60fdc88f6bc0a80d756e6205 (MD5); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); A pesquisa e o uso de plantas inseticidas têm aumentado nos últimos anos. Sua co...

Synthesis and biological evaluation of biaryl analogs of antitubulin compounds

ABSTRACT - This paper reports the synthesis of methanones and esters bearing different substitution patterns as spacer groups between aromatic rings. This series of compounds can be considered phenstatin analogs. Two of the newly synthesized compounds, 5a and 5c, strongly inhibited tubulin polymerization and the binding of [3H] colchicine to tubulin, suggesting that, akin to phenstatin and combretastatin A-4, t...

Synthesis and biological activity against Trypanosoma cruzi of a substituted 1,...

Synthesis of resorcinolic lipids bearing structural similarities to cytosporone A

Inspired by the structure and biological activities of resorcinolic lipids and, particularly cytosporone A- a potent inhibitor of plantule germination and growth, we have performed the synthesis of the analogs 3-heptyl-3-hydroxy-5,7-dimethoxy-2-benzofuran-1(3H)-one (1) and 3-heptyl-3-hydroxy-4,6-dimethoxy-2-benzofuran-1(3H)-one (2). The intermediates and products were submitted to allelopathic test using Lactuc...

Chemical modifications of a natural xanthone and antimicrobial activity against...

A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized deriv...

Transformações químicas do (+)-10β,14-diol-allo-aromadendrano, isolado de dugue...

The sesquiterpene (+)-allo-aromadendrane-10β-14-diol 1 was the lead compound to the preparation of several derivatives in order to test their biological activity against A. salina, C. sphaerospermum, E. coli and S. aureus. In this way the monoalcohols (+)-viridiflorol 4, 9 and 11 were synthesized from 1 together with the acetal 6, the ketal 7, and the ketone 8. The oxirane 3 and nitrile 5 were also prepared usi...

Glicerol: um breve histórico e aplicação em sínteses estereosseletivas

Presently glycerol is considered a co-product of biodiesel industry. As the biodiesel production is exponentially increasing, glycerol generated from the transesterification of vegetable oils and fats is also being produced on a large scale, and turned out to be essential seeking for novel alternatives to the consumption of the extra volume, in crude and/or as derivatives high added value. This review mainly de...

Biotransformation of a cage-like diels-alder adduct and derivatives by Mucor ra...

The present study aimed to evaluate the ability for biotransformation of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione (1) and two synthetic derivatives by the saprobe fungus Mucor ramosissimus Samutsevitsch. Products from oxidation, isomerization and, regioselective and enantioselective reduction were achieved.; Neste trabalho avaliou-se a capacidade de biotransformação do aduto de Diels...

Synthesis of angiotensin-converting enzyme (ACE) inhibitors: an important class...

ACE inhibitors are one of the most active classes of molecules that lower blood pressure. This report outlines the discovery, the design and development of new compounds, and, structure-activity relationships for this drug category. Updated approaches to planned syntheses of new worthy ACE-inhibitors are also exploited.

Constituintes químicos de Parmotrema lichexanthonicum Eliasaro & Adler - isolam...

From the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were ob...