3 documents found, page 1 of 1
Estudo da atividade anticâncer da marinobufagenina, um bufadienolídeo extraído ...
Lima, Daisy Jereissati BarbosaCancer is a complex genetic disease, considered one of the leading causes of death in the world. The use of substances derived from natural products has grown over the years and is an important source for the therapeutic arsenal. Bufadienolides, a group of cardioactive steroids with a 24 carbon structures are commonly found in glands of toads from Bufonidae family. These molecules a have wide range of biologica...
Assessing chemical constituents of Mimosa caesalpiniifolia stem bark : possible...
Monção, Nayana Bruna Nery; Araújo, Bruno Quirino; Silva, Jurandy do Nascimento; Lima, Daisy Jereissati Barbosa; Ferreira, Paulo Michel PinheiroMimosa caesalpiniifolia is a native plant of the Brazilian northeast, and few studies have investigated its chemical composition and biological significance. This work describes the identification of the first chemical constituents in the ethanolic extract and fractions of M. caesalpiniifolia stem bark based on NMR, GC-qMS and HRMS analyses, as well as an assessment of their cytotoxic activity. GC-qMS analysis ...
Cytotoxic and toxicological effects of phthalimide derivatives on tumor and nor...
Ferreira, Paulo Michel Pinheiro; Costa, Patrícia Marçal da; Costa, Arinice de Menezes; Lima, Daisy Jereissati Barbosa; Drumond, Renata RosadoEleven phthalimide derivatives were evaluated with regards to their antiproliferative activity on tumor and normal cells and possible toxic effects. Cytotoxic analyses were performed against murine tumors (Sarcoma 180 and B-16/F-10 cells) and peripheral blood mononuclear cells (PBMC) using MTT and Alamar Blue assays. Following, the investigation of cytotoxicity was executed by flow cytometry analysis and antitu...