30 documents found, page 1 of 3

22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma ...

Ethnopharmacological relevance: 22β-hydroxytingenone (22-HTG) is a quinonemethide triterpene isolated from Salacia impressifolia (Miers) A. C. Smith (family Celastraceae), which has been used in traditional medicine to treat a variety of diseases, including dengue, renal infections, rheumatism and cancer. However, the anticancer effects of 22-HTG and the underlying molecular mechanisms in melanoma cells have no...

Antifungal activity of synthetic naphthoquinones against dermatophytes and oppo...

This study evaluated the antifungal activities of synthetic naphthoquinones against opportunistic and dermatophytic fungi and their preliminary mechanisms of action. The minimum inhibitory concentrations (MICs) of four synthetic naphthoquinones for 89 microorganisms, including opportunistic yeast agents, dermatophytes and opportunistic filamentous fungi, were determined. The compound that exhibited the best act...

Erratum to: Antioxidant activity and peroxidase inhibition of Amazonian plants ...

Screening and antifungal activity of a β-carboline derivative against cryptococ...

Background. Cryptococcosis is a fungal disease of bad prognosis due to its pathogenicity and the toxicity of the drugs used for its treatment. The aim of this study was to investigate the medicinal potential of carbazole and β-carboline alkaloids and derivatives against Cryptococcus neoformans and C. gattii. Methods. MICs were established in accordance with the recommendations of the Clinical and Laboratory Sta...

Stability and antioxidant activity of semi-synthetic derivatives of 4-nerolidyl...

4-nerolidylcatechol (4-NC) is an unstable natural product that exhibits important antioxidant, anti-inflammatory and other properties. It is readily obtainable on a multi-gram scale through straightforward solvent extraction of the roots of cultivated Piper peltatum or P. umbellatum, followed by column chromatography on the resulting extract. Semi-synthetic derivatives of 4-NC with one or two substituent groups...

Anti-inflammatory, anti-hyperalgesic, antiplatelet and antiulcer activities of ...

Ethnopharmacological relevance: Decoctions or infusions of the stem bark of Byrsonima japurensis A. Juss. (Malpighiaceae) are widely used as an anti-inflammatory drug in folk medicine of Amazonas State (Brazil). Aim of the study: To evaluate the pharmacological potential of an aqueous extract of the stem bark of Byrsonima japurensis (BJEA) to scientifically verify of its traditional use. Materials and methods: ...

Effects of diet supplementation with Camu-camu (Myrciaria dubia HBK McVaugh) fr...

O fruto Camu-camu da amazônia (Myrciaria dubia HBK Mc Vaugh) apresenta um interesse atrativo na alimentação e industria de cosméticos devido ao rico conteúdo de Vitamina C, flavonoides e antocianinas. O objetivo deste estudo foi investigar a ação antiobesidade da ingestão da polpa de Camu-camu em modelo de ratos obesos. Ratos Wistars foram induzidos a obesidade pela injeção subcutânea de glutamato monossódico r...

The metabolic cost of nesting: body condition and blood parameters of Caiman cr...

Although nesting ecology is well studied in several crocodilian species, it is not known how nest attendance influences physiology and body condition of nesting females. In this study, we describe body condition and serum biochemical values of nesting female, non-nesting female and male spectacled caiman (Caiman crocodilus) and black caiman (Melanosuchus niger) in two areas of Central Amazonia. We also evaluate...

Antitumor and antibacterial activity of white and yellow venoms of Crotalus dur...

Hypoglycemic effect of Passiflora nitida Kunth fruit flour on normal and diabet...

The Amazon region has a vast biodiversity of fruits but is little explored as to its nutritional and economic potential. Among these fruits is "maracuja-do-mato" (Passiflora nitida Kunth), a wild species of edible fruit with exotic flavor and good acceptability for consumption. The aim of the present study was to analyze the nutritional characteristics of P. nitida fruit mesocarp and to evaluate its hypoglycemi...