5 documents found, page 1 of 1
Synthesis and antimetastatic activity evaluation of cinnamic acid derivatives c...
Lima, Graziela Domingues de Almeida; Rodrigues, Michelle Peixoto; Moreira, Gabriela Alves; Mendes, Tiago Antônio de Oliveira; Siqueira, Raoni PaisIt is herein described the preparation and evaluation of antimetastatic activity of twenty-six cinnamic acid derivatives containing 1,2,3-triazolic portions. The compounds were prepared using as the key step the Copper(I)-catalyzed azide (A)-alkyne (A) cycloaddition (C) (CuAAC reaction), also known as click reaction, between alkynylated cinnamic acid derivatives and different benzyl azides. The reactions were c...
Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich...
Moreira, Gabriela Alves; Lima, Graziela Domingues de Almeida; Siqueira, Raoni Pais; Barros, Marcus Vinícius de AndradeThe Serine/arginine-rich protein kinases (SRPK) are involved in pre-mRNA splicing control through the phosphorylation of the SR protein family of splicing factors. Over the last years, several studies have shown the relevance of SRPK for human cancers and their potential as promising drug targets. In this context, we have previously selected three trifluoromethyl arylamides (named here as SRVIC24, SRVIC30 and S...
Fertility in male rats: Disentangling adverse effects of arsenic compounds
Lima, Graziela Domingues de Almeida; Sertorio, Marcela Nascimento; Souza, Ana Cláudia Ferreira; Menezes, Tatiana Prata; Mouro, Viviane Gorete SilveiraArsenic impairs male reproductive functions. However, it is not clear whether different arsenic compounds similarly affect fertility. In this study, we compared the impact of sodium arsenite and arsenate on sperm quality and fertility. After 56 d exposure, male Wistar rats were mated and pregnant females were evaluated by fertility indexes. Clearly, exposure to 10 mg/L arsenite reduced daily sperm production vi...
Avaliação da atividade antimetastática em células de melanoma in vitro de compo...
Lima, Graziela Domingues de AlmeidaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; O melanoma cutâneo é um problema de saúde pública mundial, por ser um tumor sólido altamente metastático. Compostos sintéticos têm sido desenvolvidos no intuito de combater atividades das células tumorais, como migração, invasão, adesão e proliferação. Dentre eles, compostos derivados do ácido cinâmico e isobenzofuranonas têm apresentado importante at...
Fertilidade e morfofisiologia epididimária de ratos wistar submetidos a ingestã...
Lima, Graziela Domingues de AlmeidaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; The aim of this study was to compare the effect of exposure to different concentrations of arsenic in the pentavalent (arsenate, As+5) and trivalent forms (arsenite, As+3) on reproductive parameters. Were used 30 Wistar rats randomly divided into five experimental groups (n = 6 animals/group). The control animals received saline, while the treated ani...