50 documents found, page 1 of 5

Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...

Sarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...

Design and Implementation of a Collaborative Clinical Practice and Research Doc...

This paper introduces a prototype for clinical research documentation using the structured information model HL7 CDA and clinical terminology (SNOMED CT). The proposed solution was integrated with the current electronic health record system (EHR-S) and aimed to implement interoperability and structure information, and to create a collaborative platform between clinical and research teams. The framework also aim...

Consumer Perception and Acceptability of Lupin-Derived Products: A Systematic R...

The addition of lupin into other foods can enhance their nutritional value and may be an acceptable approach to introducing lupin into the food supply, particularly as an ingredient. Lupin could be used in many food products (bakery products, pasta, beverages, meat products and dairy products) to improve their protein content and possible nutraceutical effects. The main aim of this study is to summarise the rec...

Intermediate meals and the place of consumption-Which relationship?

Introduction: The distribution of energy and nutrients in 4-6 daily meals may have beneficial health effects. The place where people have their meals is frequently identified as a determinant of food consumption. Objectives: To evaluate the influence of the place where university employees, have their meals on the adequacy of intermediate meals.Methods: Data collection was carried out in face-to-face interviews...

Transferrin-Conjugated PLGA Nanoparticles for Co-Delivery of Temozolomide and B...

Glioblastoma (GBM) represents almost half of primary brain tumors, and its standard treatment with the alkylating agent temozolomide (TMZ) is not curative. Treatment failure is partially related to intrinsic resistance mechanisms mediated by the O6- methylguanine-DNA methyltransferase (MGMT) protein, frequently overexpressed in GBM patients. Clinical trials have shown that the anticancer agent bortezomib (BTZ) ...

Perda Gestacional Recorrente

Prevenção do Tromboembolismo Venoso na Gravidez, Parto e Pós-Parto: Norma de Or...

Stream sediment analysis for Lithium (Li) exploration in the Douro region (Port...

Lithium (Li) was recently added to the list of critical raw materials by the European Union due to its significance for the green energy transition. Thus, the development of new toolchains to make Li exploration more economic and more effective is needed. Stream sediment analysis can play an important part in these new tool chains. In this work, two historical stream sediment datasets covering parts of the Freg...

Aspirin Desensitization: Implications for Acetylsalicylic Acid-Sensitive Pregna...

Low-dose acetylsalicylic acid (ASA) is widely used during pregnancy to prevent obstetric complications of placental dysfunction, such as preeclampsia, stillbirth and fetal growth restriction, and obstetric complications in pregnant women with antiphospholipid syndrome. ASA-sensitive pregnant women cannot benefit from the effects of ASA due to the possibility of severe or potentially life-threatening hypersensit...

Case Report: Pheochromocytoma and Synchronous Neuroblastoma in a Family With He...

Introduction: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumours arising from chromaffin cells of the adrenal medulla or extra-adrenal sympathetic paraganglia. Recent studies have indicated that up to 40% of pheochromocytomas could be attributable to an inherited germline variant in an increasing list of susceptibility genes. Germline variants of the MYC-associated factor (MAX) gene have ...