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Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes
Dias, Catarina; Pais, João P.; Nunes, Rafael; Blázquez-Sánchez, Maria-Teresa; Marquês, Joaquim T.; Almeida, Andreia F.; Serra, Patrícia; Xavier, Nuno M.Anthrax is an infectious disease caused by Bacillus anthracis, a bioterrorism agent that develops resistance to clinically used antibiotics. Therefore, alternative mechanisms of action remain a challenge. Herein, we disclose deoxy glycosides responsible for specific carbohydrate-phospholipid interactions, causing phosphatidylethanolamine lamellar-to-inverted hexagonal phase transition and acting over B. anthrac...
“Healthy Life”: interaction of polyphenols with lipid bilayers and their effect...
Filipe, Hugo A. L.; Peneda, Catarina; Marquês, Joaquim T.; Machuqueiro, Miguel; Ramos, João C.; Santos, Maria da Soledade; Marinho, H. SusanaThis work concerns the transversal project of the CQB thematic line: “Healthy Life: Molecular Interventions and Regulation Mechanisms”. Biologically active plant phytochemicals have a broad range of pharmacological effects including anticarcinogenic, antimicrobial, antioxidant, and anti-inflammatory activity. [1] Notwithstanding the possibility of having a specific target, phytochemicals must interact and perme...