7 documents found, page 1 of 1
Statins Prevent Biochemical Recurrence of Prostate Cancer After Radical Prostat...
Jarimba, Roberto; Lima, João Pedroso; Eliseu, Miguel; Carvalho, João; Antunes, Hugo; Silva, Edgar Tavares da; Moreira, Pedro; Figueiredo, ArnaldoIntroduction: Prostate cancer is the most commonly diagnosed cancer in men. Radical prostatectomy is a potentially curative alternative for localized disease, although a significant percentage of these patients will suffer a biochemical recurrence with associated mortality. A wide spectrum of anticancer properties of statins has been demonstrated and the role of these drugs in prevention and treatment of other ...
Contributo da PET/CT com Fluorocolina-F18 na Radioterapia Externa do Carcinoma ...
Lapa, Paula; Jacobetty, Miguel; Marques, Margarida; Costa, Gracinda; Borrego, Margarida; Lima, João PedrosoObjetivo: A radioterapia é uma opção terapêutica no carcinoma da próstata. Pretendemos avaliar o contributo da PET/CT com Fluorocolina-F18(FCH-F18) na identificação dos doentes com indicação para essa estratégia terapêutica e o impacto no seu planeamento. Material e Métodos: Analisámos retrospetivamente 282 PET/CT com FCH-F18. Seleccionámos 187 doentes sem antecedentes de radioterapia prévia (41 estadiamentos i...
Avaliação de hipóxia tumoral por PET/CT com fluoromisonidazol(18 F) no planeame...
Lapa, Paula; Jacobetty, Miguel; Teixeira, Tânia; Silva, Rodolfo; Saraiva, Tiago; Ferreira, Rui; Costa, Gracinda; Borrego, Margarida; Lima, João PedrosoA hipóxia está frequentemente presente nos tumores sólidos malignos, encontrando-se associada a agressividade tumoral e a resistência à terapêutica. A sua detecção tem elevada importância clínica porque o prognóstico das lesões malignas com baixos níveis de oxigenação é desfavorável. O Fluoromisonidazol (18 F) (FMISO-F18) é um radiofármaco desenvolvido com o objectivo de identificar hipóxia tumoral. Há forte ev...
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with ...
Lapa, Paula; Saraiva, Tiago; Silva, Rodolfo; Marques, Margarida; Costa, Gracinda; Lima, João PedrosoIntroduction: The 18F-NaF positron emission tomography/computed tomography is being considered as an excellent imaging modalityfor bone metastases detection. This ability was compared with other imaging techniques.Material and Methods: We retrospectively evaluated 114 patients who underwent 18F-NaF positron emission tomography/ computed tomography. Of these, 49 patients also had bone scintigraphy, 61 18F-FDG po...
PET/CT with 18F-Fluorocholine in Patients with Prostatic Cancer in Biochemical ...
Lapa, Paula; Silva, Rodolfo; Saraiva, Tiago; Figueiredo, Arnaldo; Ferreira, Rui; Costa, Gracinda; Lima, João PedrosoIntroduction: In prostate cancer, after therapy with curative intent, biochemical recurrence frequently occurs. The purpose of this study was to evaluate the impact of PET/CT with 18F-fluorocholine in restaging these patients and in their orientation, and to analyze the effect of the risk stratification, the values of PSA and the hormone suppression therapy, in the technique sensitivity. Material and Methods: R...
Radiologia e Medicina Nuclear
Lima, João PedrosoAs descobertas da radiaçao X (Roentgen, 1895) e da radioactividade (Becquerel, 1896) aconteceram praticamente na mesma altura. A radiologia e a medicina nuclear, como actualmente as conhecemos, devem a sua origem àquelas descobertas fundamentais e são hoje instrumentos imprescindíveis ao exercício da prática médica. Sendo quase gémeas pelo seu nascimento, partilham ainda outra característica de família: ambas s...
SENTINEL NODE BIOPSY IN PORTUGAL - THE EXPERIENCE OF A REFERENCE A CENTER
Teixeira, Vera; Vieira, Ricardo; Coutinho, Inês; Cabral, Rita; Andrade, Pedro; Julião, Maria José; Brites, Maria Manuel; Albuquerque, AnabelaBackground: Sentinel lymph node biopsy is undertaken as a standard procedure for patients with localized cutaneous melanoma. The National Comprehensive Cancer Network (NCCN) melanoma panel has reinforced the status of Sentinel lymph node biopsy as the most important prognostic factor for disease survival.Objectives: We sought to identify predictive factors associated with positive SLN biopsy and correlation wit...