31 documents found, page 1 of 4
Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...
Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, PauloSarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...
Microvascular, biochemical, and clinical impact of hyperbaric oxygen therapy in...
Martins-Mendes, Daniela; Costa, Raquel; Rodrigues, Ilda; Camacho, Óscar; Coelho, Pedro Barata; Paixão-Dias, Vítor; Luís, Carla; Pereira, Ana CláudiaBackground: Diabetic foot ulcers (DFUs) are a serious complication of diabetes and are often difficult to treat. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment to promote healing, but its long-term clinical and biological effects remain insufficiently characterized. This study aimed to evaluate the impact of HBOT on systemic biomarkers, local microvasculature, and clinical outcome...
Abnormal p53 High-Grade Endometrioid Endometrial Cancer
Casanova, Joao; Babiciu, Alexandru-romualdo; Duarte, Gonçalo S; da Costa, Ana Gomes; Silvério Serra, Sofia; Costa, Teresa; Catarino, AnaPublisher Copyright: © 2024 by the authors.; Objective: Our primary objective was to evaluate the oncologic outcomes of patients with abnormal p53 FIGO grade 3 (high-grade) endometrioid endometrial cancer. As secondary objectives, we determined the global prevalence of abnormal p53 in grade 3 endometrioid endometrial carcinomas and the geographical variations. Methods: The following electronic databases were se...
Case Report
Tripepi, Marta; da Costa, Ana G.; Albergaria, Diogo; Costa, Andreia; Catarino, Ana; Duarte, Ana Luisa; Bartosch, Carla; Schuler, VeronicaPublisher Copyright: Copyright © 2025 Tripepi, da Costa, Albergaria, Costa, Catarino, Duarte, Bartosch, Schuler, Oliveira, Lima and Casanova.; Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare, highly aggressive malignancy that predominantly affects young women. We report a 32-year-old pregnant woman diagnosed with SCCOHT during the first trimester of pregnancy. At 24 weeks, imaging reve...
Small cell carcinoma of the ovary, hypercalcemic type
Tripepi, Marta; da Costa, Ana G.; Chi, Dennis S.; Lima, Jorge; Casanova, JoãoPublisher Copyright: Copyright © 2025 Tripepi, da Costa, Chi, Lima and Casanova.; Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly aggressive ovarian neoplasm, predominantly affecting young women, often in their second or third decade of life. Despite its distinctive clinical and pathological features, diagnosis is frequently delayed due to overlapping characteristics with oth...
Efficacy of therapeutic interventions for idiopathic recurrent pregnancy loss
Lima, Jorge; Guerreiro, João; Ângelo-Dias, Miguel; Silvério Serra, Sofia; Costa, Teresa; Marto, Natália; de Pinho, João Feldman; Costa, JoãoFunding Information: The author(s) declare that financial support was received for the research and/or publication of this article. This study in the context of the \u201CWomen\u2019s Health and Maternal Fetal Research Group\u201D was partially co-financed by Hospital da Luz Lisboa under the initiative \u201CLuz Investiga\u00E7\u00E3o.\u201D The sponsor did not have any role in the study design, in the collecti...
Safety of fibrinogen concentrate in non-trauma and non-obstetric adult patients...
Gomes, Manuela; Ângelo-Dias, Miguel; S Duarte, Gonçalo; Dias, Sara Simões; Silvério Serra, Sofia; Lima, JorgeBackground: Low fibrinogen levels are associated with an increased risk of perioperative bleeding. However, there is an ongoing debate over the ideal treatment threshold, the benefits of prophylactic supplementation with fibrinogen concentrate, and the best source of fibrinogen. While fibrinogen concentrate supplementation is being widely used to treat bleeding related to acquired haemostatic deficiencies, ther...
Safety of Fibrinogen Concentrate for Correcting Perioperative Bleeding-Associat...
Gomes, Manuela; Ângelo-Dias, Miguel; Lima, JorgePublisher Copyright: © 2024 by the authors.; Background: Surgery often leads to bleeding associated with hypofibrinogenemia. Supplementation with fibrinogen concentrate appears to be effective and safe, although findings from studies are inconsistent. The primary aim of this study was to assess the safety of fibrinogen concentrate during the perioperative period. Methods: This single-centre, prospective, observ...
The Role of NK and T Cells in Endometriosis
Reis, José; Rosa, Natacha Nurdine; Martins, Catarina; Ângelo-Dias, Miguel; BORREGO, LUIS MIGUEL; Lima, JorgeEndometriosis, a debilitating condition, affects one in ten women of reproductive age. Its pathophysiology remains unclear, though deficiencies in immune surveillance are thought to create an environment conducive to the evasion of ectopic endometrial cells from the immune system. Our research explores the immunological impact of endometriosis both locally and systemically, emphasizing natural killer (NK) and T...
Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endo...
Casanova, Joao; Duarte, Gonçalo Silva; da Costa, Ana Gomes; Catarino, Ana; Nave, Mónica; Antunes, Telma; Serra, Sofia Silvério; Dias, Sara SimõesBackground. POLE mutated endometrial carcinomas may represent a subspecific type of tumors harboring a more favorable prognosis. Grade 3 (G3 or high-grade) endometrioid endometrial carcinomas remain a clinical dilemma, with some tumors behaving as the low-grade counterparts and others presenting a more aggressive behavior. Objectives. To determine the association between POLE mutational status and the overall-s...