5 documents found, page 1 of 1
Natural products as new antimitotic compounds for anticancer drug development
Paier, Carlos Roberto Koscky; Maranhão, Sarah Sant’Anna; Carneiro, Teiliane Rodrigues; Lima, Lídia Moreira; Rocha, Danilo DamascenoCell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. These antitumor compounds are referred to as antimitotics....
Synthesis, aqueous solubility, metabolic stability and pharmacological profile ...
Lima, Lídia Moreira
Docking, synthesis and antiproliferative activity of N-acylhydrazone derivative...
Amaral, Daniel Nascimento do; Cavalcanti, Bruno C.; Bezerra, Daniel P.; Ferreira, Paulo Michel P.; Castro, Rosane de Paula; Sabino, José RicardoCancer is the second most common cause of death in the USA. Among the known classes of anticancer agents, the microtubule-targeted antimitotic drugs are considered to be one of the most important. They are usually classified into microtubule-destabilizing (e.g., Vinca alkaloids) and microtubule-stabilizing (e.g., paclitaxel) agents. Combretastatin A4 (CA- 4), which is a natural stilbene isolated from Combretum ...
Docking, synthesis and pharmacological activity of novel urea-derivatives desig...
Lima, Lídia Moreira
Therapeutic approaches for tumor necrosis factor inhibition
Barbosa, Maria Letícia de Castro; Fumian, Milla Machado; Miranda, Ana Luísa Palhares de; Barreiro, Eliezer J.; Lima, Lídia MoreiraTumor necrosis factor (TNF) consists of an inflammatory cytokine essential for homeostasis and organism defense. Despite its physiological relevance, both increased biosynthesis and release of TNF lead to the exacerbation of inflammatory and oxidative responses, which are related to the pathogenesis of a host of diseases of an inflammatory, autoimmune and/or infectious nature. In this context, effective therape...