7 documents found, page 1 of 1
Overview of bioremediation with technology assessment and emphasis on T fungal ...
Quintella, Cristina; Mata, A. M. T.; Lima, LeandroEnvironmental contamination is a problem that requires sustainable solutions. Bioremediation technologies have been developed in the last decades and are increasingly used to mitigate environmental accidents and systematic contaminations. A review of bioremediation technologies, based on published article and patent documents, is presented for different types of contaminated matrices, bioremediation agents and ...
Genome-wide analyses identify KIF5A as a novel ALS gene
Nicolas, Aude; Kenna, Kevin P.; Renton, Alan E.; Ticozzi, Nicola; Faghri, Faraz; Chia, Ruth; Dominov, Janice A.; Kenna, Brendan J.; Nalls, Mike A.To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Int...
Co-expression network of neural-differentiation genes shows specific pattern in...
Maschietto, Mariana; Tahira, Ana C.; Puga, Renato; Lima, Leandro; Mariani, Daniel; Paulsen, Bruna da Silveira; Belmonte-de-Abreu, PauloBackground: Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors contributing to its pathogenesis, although the mechanism is unknown due to the difficulties in accessing diseased tissue during human neurodevelopment. The aim of this study was to find neuronal differentiation genes disrupted in schizophrenia and to evaluate those genes in post-mortem brain tissues from schizophre...
Alterações morfológicas da conjuntiva de coelhos submetidos a tratamento com fá...
Lima, LeandroOrientador : Prof. Dr. Fabiano Montiani-Ferreira; Tese (doutorado) - Universidade Federal do Paraná, Setor de Ciências Agrárias, Programa de Pós-Graduação em Ciências Veterinárias. Defesa: Curitiba, 03/12/2014; Inclui referências : f. 95-99; Resumo: A presente tese de doutorado está dividida em quatro capítulos. O primeiro capítulo, que será enviado ao periódico Arquivos Brasileiros de Oftalmologia Veterinária,...
Innate immune response is differentially dysregulated between bipolar disease a...
Baumont, Angelica de; Maschietto, Mariana; Lima, Leandro; Carraro, Dirce Maria; Olivieri, Eloisa Helena; Fiorini, Alex; Barreta, Luiz André NardinSchizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions with a neurodevelopmental component. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. Also, image studies provide evidence for a shared neurobiological basis, contributing to a dimensional diagnostic approach. This study aimed to identify the molecular mechanisms that differentiate...
Gene expression of peripheral blood lymphocytes may discriminate patients with ...
Palha, Joana Almeida; Maschietto, Mariana; Silva, Aderbal R.; Puga, Renato; Lima, Leandro; Pereira, Carlos B.; Nakano, Eduardo Y.; Mello, BarbaraTo identify a classifier in schizophrenia, blood gene expression profiling was applied to patients with schizophrenia under different treatments and to controls. Expression of six genes discriminated patients with sensitivity of 89.3% and specificity of 90%, supporting the use of peripheral blood as biological material for diagnosis in schizophrenia.
Contribuições para oftalmologia clínica, cirúrgica e investigativa de animais d...
Lima, LeandroResumo: A presente pesquisa buscou contribuir com a oftalmologia clínica, cirúrgica e investigativa de animais domésticos, selvagens e de mascotes não convencionais. Para isso, o trabalho foi subdividido em três capítulos independentes entre si. No primeiro capítulo, o enfoque da pesquisa foi descrever uma técnica operatória de facofragmentação com alça de náilon em cães acometidos por catarata com luxação ante...