64 documents found, page 1 of 7
A preliminary assessment of a stool-based microRNA profile for early colorectal...
Santos, Daniela A. R.; Eiras, Mariana; Gonzalez-Santos, Miguel; Santos, Marlene; Pereira, Carina; Santos, Lúcio Lara; Dinis-Ribeiro, Mário; Lima, LuísColorectal cancer screening methods are well established worldwide as a fundamental pilar in CRC management, namely through non-invasive faecal occult blood testing. However, the limited sensitivity of faecal occult blood test for detecting precancerous lesions highlights the need to search for alternative tools, such as microRNAs (miRs). The main aim of this study was to identify stoolbased miR profiles for ea...
Detecting Candida spp. through an innovative genosensor
Castanheira, Michelle; Morais, Stephanie; Lima, Luís; Santos, Marlene; Barroso, M. Fátima; Santos, MarleneCandida spp. is the second most common cause of invasive fungal infection in hematopoietic stem cell transplantation (HSCT) patients and are associated with high mortality rates, ranging from 40 to 90%. Timely and accurate diagnosis is crucial for successful HSCT treatment. Current diagnostic methods, relying on conventional approaches, have limitations. Molecular and serological tests, although accurate, are t...
Challenging invasive fungal infections: development of innovative electrochemic...
Castanheira, Michelle; Morais, Stephanie L.; Seguro, Isabel; Santos, Marlene; Lima, Luís; Pacheco, João; Barroso, M. FátimaDespite the considerable advances in the prevention and treatment of fungal infections, invasive fungus such as Candida spp., continues to be one of the major causes of morbidity and mortality. The Global Action Fund Infections reported that, annually, more than 300 million people are infected with fungal infection, from these, about 1.5 million ends up dying. Candida albicans is the most important fungal 66 op...
ABCB1 C1236T, G2677TA and C3435T genetic polymorphisms and antidepressant respo...
Santos, Marlene; Lima, Luís; Carvalho, Serafim; Brandão, Andreia; Barroso, Fátima; Cruz, Agostinho; Medeiros, RuiP-glycoprotein (P-GP) is a transporter molecule expressed on the apical surface of capillary endothelial cells of the Blood–Brain Barrier (BBB), whose activity heavily influences drug distribution, including antidepressants. This transporter is encoded by ABCB1 gene, and genetic variations within ABCB1 gene have been proposed to affect drug efflux and have been previously associated with depression. In this con...
MicroRNAs Biomarkers for Early Screening of Colorectal Cancer
Santos, Daniela; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísBackground: Colorectal cancer (CRC) is the most incident neoplasia in Portugal [1]. When diagnosed early, the 5-year cancer survival rate increases to 90% [2]. However, the current noninvasive screening method for CRC, Fecal Immunochemical Test (FIT), has low sensitivity and specificity for detecting precancerous lesions [3, 4]. Therefore, it is necessary to develop a new screening method for CRC. MicroRNAs (mi...
MicroRNA biomarkers as promising tools for early colorectal cancer screening—a ...
Santos, Daniela A. R.; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísColorectal cancer (CRC) ranks as the third most prevalent cancer worldwide. Early detection of this neoplasia has proven to improve prognosis, resulting in a 90% increase in survival. However, available CRC screening methods have limitations, requiring the development of new tools. MicroRNA biomarkers have emerged as a powerful screening tool, as they are highly expressed in CRC patients and easily detectable i...
MicroRNAs biomarkers for early screening of colorectal cancer
Santos, Daniela; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísColorectal cancer (CRC) is the most incident neoplasia in Portugal. When diagnosed early, the 5-year cancer survival rate increases to 90% [2]. However, the current noninvasive screening method for CRC, Fecal Immunochemical Test (FIT), has low sensitivity and specificity for detecting precancerous lesions. Therefore, it is necessary to develop a new screening method for CRC. MicroRNAs (miRs) play a role in gene...
A Cidade do Depois: História(s), Imagens, Cinema, Política
Lima, Luís; Martins, Alexandra; Pereira, Beatriz; Rosa, Beatriz; Queirós, Francisca; Moreira, Luana; Conceição, MartaA presente edição reúne as transcrições de três conversas realizadas no âmbito do Fórum do Real, promovido pelo festival de cinema Porto/Post/Doc, no final de 2020, em torno da temática "A Cidade do Depois". Tendo como referência um conjunto de filmes programados e convocando artistas, críticos e académicos, as conversas incidiram sobre a cidade como epicentro da transformação das relações sociais e culturais n...
Cristais Cinemáticos em A Chuva é Cantoria na Aldeia dos Mortos, de João Salavi...
Lima, Luís; Martins, AlexandraVersando fundamentalmente sobre o filme Chuva é Cantoria na Aldeia dos Mortos (2018), de João Salaviza e Renée Nader Messora, este artigo pretende problematizar as relações entre os regimes de percepção das ontologias ameríndias, nomeadamente dos Krahô, e a fenomenologia do cinema, elaborando para tal três questões primordiais: 1) a relação convocada pelo filme entre animismo, xamanismo e as próprias qualidades...
Cristais cinemáticos em Chuva é Cantoria na Aldeia dos Mortos, de João Salaviza...
Lima, Luís; Martins, AlexandraVersando fundamentalmente sobre o filme Chuva é Cantoria na Aldeia dos Mortos (2018), de João Salaviza e Renée Nader Messora, este artigo pretende problematizar as relações entre os regimes de percepção das ontologias ameríndias, nomeadamente dos Krahô, e a fenomenologia do cinema, elaborando para tal três questões primordiais: 1) a relação convocada pelo filme entre animismo, xamanismo e as próprias qualidades...