2 documents found, page 1 of 1
Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis
Santarino, Inês B.; Viegas, Michelle S.; Domingues, Neuza S.; Ribeiro, Ana M.; Soares, Miguel P.; Vieira, Otília V.Erythrophagocytosis, the phagocytic removal of damaged red blood cells (RBC), and subsequent phagolysosome biogenesis are important processes in iron/heme metabolism and homeostasis. Phagolysosome biogenesis implies the interaction of nascent phagosomes with endocytic compartments and also autophagy effectors. Here, we report that besides recruitment of microtubule-associated protein-1-light chain 3 (LC3), addi...
Cholesteryl hemiesters alter lysosome structure and function and induce proinfl...
Domingues, Neuza; Estronca, Luís M.B.B.; Silva, João; Encarnação, Marisa R.; Mateus, Rita; Silva, Diogo Pinto Lobo Jesus; Santarino, Inês B.Rationale: Cholesteryl hemiesters are oxidation products of polyunsaturated fatty acid esters of cholesterol. Their oxo-ester precursors have been identified as important components of the "core aldehydes" of human atheromata and in oxidized lipoproteins (Ox-LDL). We had previously shown, for the first time, that a single compound of this family, cholesteryl hemisuccinate (ChS), is sufficient to cause irreversi...