7 documents found, page 1 of 1
Different ability of multidrug-resistant and-sensitive counterpart cells to rel...
Sousa, D; Lima, RT; Lopes-Rodrigues, V; Gonzalez, E; Royo, F; Xavier, CPR; Falcón-Pérez, JM; Vasconcelos, MHCancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. Some studies have previously described the important role of extracellular vesicles (EVs) in the dissemination of a MDR phenotype. EVs’ cargo may include different players of MDR, such as microRNAS and drug-efflux pumps, which may be...
Lrp1b: A giant lost in cancer translation
Príncipe, C; Sousa, IJD; Prazeres, H; Soares, P; Lima, RTLow-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR protein family, which includes several structurally homologous cell surface receptors with a wide range of biological functions from cargo transport to cell signaling. LRP1B is among the most altered genes in human cancer overall. Found frequently inactivated by several genetic and epigenetic mechanisms, it has mostly been...
Deep sequencing analysis reveals distinctive non-coding RNAs when comparing tum...
Sousa, D; Matthiesen, R; Lima, RT; Vasconcelos, MHMultidrug resistance (MDR) is one of the main limitations of cancer treatment. The overexpression of drug-eux pumps, such as P-glycoprotein (P-gp), is a major cause of MDR. Importantly, di erent studies have shown that extracellular vesicles (EVs) participate in the communication between MDR cells and drug-sensitive counterparts, promoting dissemination of the MDR phenotype. In the present work, we aimed to ide...
Predictive biomarkers and patient outcome in platinum-resistant (PLD-treated) o...
Sousa, IJD; Marques, DS; Príncipe, C; Portugal, RV; Canberk, S; Prazeres, H; Lopes, JM; Gimba, ERP; Lima, RT; Soares, PIdentification of predictive biomarkers for ovarian cancer (OC) treatment, particularly in the platinum-resistant/refractory setting, is highly relevant for clinical management. E-cadherin, vimentin, and osteopontin (OPN) are proteins associated with tumor microenvironment (TME) remodelling that play key roles in cancer. This study aimed to evaluate the association between the staining patterns of these protein...
Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone ...
Pereira, D; Lima, RT; Palmeira, A; Seca, H; Soares, J; Gomes, S; Raimundo, L; Maciel, C; Pinto, M; Sousa, E; Vasconcelos, MH; Saraiva, L; Cidade, HThe virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol reactions. The activity of these compounds as inhibitors of p53–MDM2 interaction was investigated using a yeast-based screening assay. Using this approach two chalcone...
Synthesis and evaluation of the tumor cell growth inhibitory potential of new p...
Bizarro, A; Sousa, D; Lima, RT; Musso, L; Cincinelli, R; Zuco, V; Cesare, M; Dallavalle, S; Vasconcelos, MHBackground: Heat shock protein 90 (HSP90) is a well-known target for cancer therapy. In a previous work, some of us have reported a series of 3-aryl-naphtho[2,3-d]isoxazole-4,9-diones as inhibitors of HSP90. Methods: In the present work, various compounds with new chromenopyridinone and thiochromenopyridinone scaffolds were synthesized as potential HSP90 inhibitors. Their binding affinity to HSP90 was studied i...
OPNa overexpression is associated with matrix calcification in thyroid cancer c...
Ferreira, LB; Lima, RT; Bastos, A; Silva, AM; Tavares, C; Pestana, A; Rios, E; Eloy, C; Sobrinho-Simões, M; Gimba, E; Soares, POsteopontin (OPN) spliced variants (OPN-SV: OPNa, OPNb, and OPNc) are aberrantly expressed in tumors and frequently associated with cancer progression. This holds true for papillary thyroid carcinoma (PTC), which is the most common type of thyroid cancer (TC). PTC often presents with desmoplasia and dystrophic calcification, including psammoma bodies (PB). This work aimed to investigate total OPN (tOPN) and OPN...