16 documents found, page 1 of 2
In vitro inhibitory activity of terpenic derivatives against clinical and envir...
Brilhante, Raimunda Sâmia Nogueira; Marques, Natalya Fechine Silva; Castelo-Branco, Débora de Souza Collares Maia; Lima, Rita Amanda Chaves deSporotrichosis is a subacute or chronic subcutaneous infection, caused by the fungus Sporothrix schenkii complex, occurring in human and animal tissues. Potassium iodide and itraconazole have been used as effective therapy for first-choice treatment, while am- photericin B may be indicated for disseminated infection. However, the adverse effects of potassium iodide and amphotericin B or the long duration of the...
Easy storage strategies for sporothrix spp. strains
Brilhante, Raimunda Sâmia Nogueira; Silva, Natalya Fechine; Lima, Rita Amanda Chaves de; Caetano, Érica Pacheco; Alencar, Lucas Pereira deThe present study evaluated the maintenance of Sporothrix spp. (6 Sporothrix brasiliensis;6S. schenckii;5 S. mexicana, and 3 S. globosa) in saline at 4 C, and in 10% glycerol plus either 10% lactose or 10% sucrose, at -20 C and -80 C. Viability was assessed after 3, 6, and 9 months of storage, through the recovery of strains on potato dextrose agar and analysis of macro- and micromorphological features. Conidiu...
Estudos dos fungos dimórficos Coccidioides posadasii e Histoplasma capsulatum v...
Lima, Rita Amanda Chaves deDimorphic fungi Coccidioides spp. and Histoplasma capsulatum var. capsulatum are the causative agents of coccidioidomycosis and histoplasmosis, respectively, being able to affect humans and other animals. The population genetics of H. capsulatum var. capsulatum ha ve been characterized worldwide. However, there are few studies of g enetic variability for Coccidioides spp., especially in isolates from Brazil. In...
Coccidioides posadasii de origem clínica e ambiental : um estudo da diversidade...
Lima, Rita Amanda Chaves deCoccidiodomycosis is a systemic infection, predominantly pulmonary, caused by the geophilic and dimorphic fungi, Coccidioides immitis and Coccidioides posadasii. In Brazil, coccidioidomycosis is associated with semi-arid areas in the Northeastern region of this country, which is considered one of the endemic areas of this disease in South America. These pathogens are morphologically indistinguishable species, b...
Farnesol against Coccidioides posadasii : its effect on growth, ergosterol
Brilhante, Raimunda Sâmia Nogueira; Lima, Rita Amanda Chaves de; Caetano, Erica Pacheco; Leite, João Jaime GiffoniCoccidioidomycosis is a systemic mycosis caused by the dimorphic fungi Coccidioides spp. The treatment for chronic and/or disseminated coccidioidomycosis can be prolonged and complicated. Therefore, the search for new drugs is necessary. Farnesol is a precursor in the sterol biosynthesis pathway that has been shown to present antifungal activity. Thus, the objective of this study was to evaluate the in vitro an...
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to...
Medrano, Delia Jessica Astete; Cordeiro, Rossana de Aguiar; Marques, Francisca Jakelyne de Farias; Andrade, Heuziwanne Tavares LeiteThe aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The m...
Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in...
Caetano, Erica Pacheco; Brilhante, Raimunda Sâmia Nogueira; Lima, Rita Amanda Chaves de; Leite, João Jaime GiffoniCoccidioidomycosis is a systemic mycosis caused by the dimorphic fungi Coccidioides spp. The treatment for chronic and/or disseminated coccidioidomycosis can be prolonged and complicated. Therefore, the search for new drugs is necessary. Farnesol is a precursor in the sterol biosynthesis pathway that has been shown to present antifungal activity. Thus, the objective of this study was to evaluate the in vitro an...
Ciprofloxacin shows synergism with classical antifungals against Histoplasma ca...
Caetano, Erica Pacheco; Brilhante, Raimunda Sâmia Nogueira; Sidrim, José Júlio Costa; Cordeiro, Rossana de Aguiar; Camargo, Zoilo Pires deThis study evaluated the in vitro interaction between ciprofloxacin (CIP) and classical antifungals against Histoplasma capsulatum var. capsulatum in mycelial (n = 16) and yeast-like forms (n = 9) and Coccidioides posadasii in mycelial form (n = 16). This research was conducted through broth microdilution and macrodilution, according to Clinical Laboratory Standards Institute. Inocula were prepared to obtain fr...
Synergistic Effect of Antituberculosis Histoplasma capsulatum var. capsulatum D...
Caetano, Érica Pacheco; Cordeiro, Rossana de Aguiar; Marques, Francisca Jakelyne de Farias; Brilhante, Raimunda Sâmia NogueiraThis study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plu...
Feline histoplasmosis in Brazil : clinical and laboratory aspects and a compara...
Brilhante, Raimunda Sâmia Nogueira; Coelho, Camila Gomes Virginio; Sidrim, José Júlio Costa; Lima, Rita Amanda Chaves de; Ribeiro, Joyce FontelesThe present study described clinical and epidemiological aspects of three cases of feline histoplasmosis and compared them to previously described cases. A detailed mycological identification and antifungal susceptibility profile of each isolate are presented. Secondarily, a serological survey for anti- Histoplasma antibodies was performed with domestic and wild cats. Diseased animals presented nodular to ulcer...