101 documents found, page 1 of 11
Placental microphysiological systems: new advances on promising platforms that ...
Gonçalves, Inês M.; Afzal, Muhammad; Kennedy, Nithil; Moita, Ana; Lima, Rui Alberto Madeira Macedo; Ostrovidov, Serge; Hori, Takeshi; Nashimoto, YujiOne of the most complex human physiological processes to study is pregnancy. Standard animal models, as well as two-dimensional models, lack the complexity and biological relevance required to accurately study such a physiological process. Recent studies have focused on the development of three-dimensional models based on microfluidic systems, designated as placental microphysiological systems (PMPSs). PMPS dev...
Numerical and experimental analysis of mixing efficiency in passive micromixers...
Ferreira, Filipe Maurício Santos; Sousa, Paulo Jorge Teixeira; Minas, Graça; Lima, Rui Alberto Madeira Macedo; Pinto, Vânia Cristina GonçalvesPassive micromixers play a critical role in microfluidic applications, particularly in lab-on-a-chip devices, since they do not require external energy input, being simpler, cheaper and portable. This paper reports the mixing efficiency by numerical simulation (using COMSOL Multiphysics) and by experimental validation of two 2D polydimethylsiloxane micromixer geometries. The tested flow rate ratios, 1:1, 1:4 an...
Optical sensor system to monitor the pH of circulating media on biomimetic micr...
Mendes, Fernando; Miranda, Inês Sofia Ferreira; Rodrigues, Raquel Oliveira; Ferreira, Gabriel Malheiro; Schütte, Helmut; Gassmann, StefanpH is a physiological parameter of great importance in biomedical research. For example, during cell growth process, pH is usually lowered due to the acidic metabolites released by the cells. This decrease on the pH value can affect biological processes and, consequently, affect the accuracy of the research. To monitor the pH changes along cell engineering experiments, cell culture media is usually complemented...
Long-term hydrophilic PDMS surfaces using Brij L4: A simple and robust approach...
Minas, Graça; Pinho, Diana; Borges, Joel; Vaz, Filipe; Zille, Andrea; Lima, Rui Alberto Madeira MacedoPolydimethylsiloxane (PDMS) is a widely used material in the production of microfluidic devices and biomodels, due to its exceptional mechanical, chemical and biocompatible properties. Recently, a novel class of devices known as microphysiological systems have emerged, combining microfluidic technology and cell culture, mimicking the microphysiological features of the human body to facilitate the study of both ...
Green synthesis of nanoparticles from olive oil waste for environmental and hea...
Afonso, Inês Maria Santos; Cardoso, Beatriz; Nobrega, Glauco; Minas, Graça; Ribeiro, João E.; Lima, Rui Alberto Madeira MacedoEnvironmental degradation is a growing concern, driving researchers to explore eco-friendly nanoparticle (NP) synthesis, for diverse applications. Within this context, the employment of olive oil waste (OOW) as a green source for the synthesis of NPs has emerged as a viable alternative to conventional techniques. The olive industry has a significant impact in the Mediterranean region, and alongside it, comes th...
An overview of the recent advances in pool boiling enhancement materials, struc...
Pereira, José; Souza, Reinaldo; Lima, Rui Alberto Madeira Macedo; Moreira, António; Moita, AnaThis review attempts to provide a comprehensive assessment of recent methodologies, structures, and devices for pool boiling heat transfer enhancement. Several enhancement approaches relating to the underlying fluid route and the capability to eliminate incipient boiling hysteresis, augment the nucleate boiling heat transfer coefficient, and improve the critical heat flux are assessed. Hence, this study address...
PDMS porous microneedles used as engineered tool in advanced microfluidic devic...
Maia, Renata Patrícia Faria; Sousa, Paulo Jorge Teixeira; Pinto, Vânia Cristina Gonçalves; Soares, Delfim; Lima, Rui Alberto Madeira MacedoThe advancement of organ-on-a-chip (OoC), as end-use preclinical tool, has been slackened with the techno logical and engineering challenges that in-situ real-time monitoring of physicochemical and biological param eters still represent. In this study, the envisioned solution to surpass this challenge is the integration of a microneedle (MN) patch into a microfluidic device to collect cell culture media directl...
A review of methods to modify the PDMS surface wettability and their applications
Neves, Lucas B.; Afonso, Inês S.; Nobrega, Glauco; Barbosa, Luiz G.; Lima, Rui Alberto Madeira Macedo; Ribeiro, João E.Polydimethylsiloxane (PDMS) has attracted great attention in various fields due to its excellent properties, but its inherent hydrophobicity presents challenges in many applications that require controlled wettability. The purpose of this review is to provide a comprehensive overview of some key strategies for modifying the wettability of PDMS surfaces by providing the main traditional methods for this modifica...
Polydimethylsiloxane surface modification of microfluidic devices for blood pla...
Gonçalves, Margarida; Gonçalves, Inês Maia; Borges, Joel; Faustino, Vera Luísa Carreira; Soares, Delfim; Vaz, Filipe; Minas, GraçaOver the last decade, researchers have developed a variety of new analytical and clinical diagnostic devices. These devices are predominantly based on microfluidic technologies, where biological samples can be processed and manipulated for the collection and detection of important biomolecules. Polydimethylsiloxane (PDMS) is the most commonly used material in the fabrication of these microfluidic devices. Howev...
Advances in microfluidic systems and numerical modeling in biomedical applicati...
Ferreira, Mariana; Carvalho, Violeta Meneses; Ribeiro, João; Lima, Rui Alberto Madeira Macedo; Teixeira, S. F. C. F.; Pinho, DianaThe evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools in disease diagnosis, treatment, and monitoring. Numerical simulation has emerged as a tool of increasing importance for better understanding and predicting fluid-flow behavior in microscale devices. This review explores fabrication techniques and common materials of m...