8 documents found, page 1 of 1
Pre-clinical assessment of Roflumilast therapy in a thoracic model of spinal co...
Sousa, Carla S.; Lima, Rui Augusto Ribeiro; Cibrão, Jorge R.; Gomes, Eduardo D.; Fernandes, Luís S.; Pinho, Tiffany Santos; Silva, DeolindaThe failure of axons to regenerate after a spinal cord injury (SCI) remains one of the greatest challenges in neuroscience. The initial mechanical trauma is followed by a secondary injury cascade, creating a hostile microenvironment, which not only is not permissive to regeneration but also leads to further damage. One of the most promising approaches for promoting axonal regeneration is to maintain the levels ...
Multi-material cellular structured orthopedic implants design: in vitro and bio...
Costa, Ana Mafalda Meneses; Lima, Rui Augusto Ribeiro; Alves, N.; Silva, Nuno André Martins; Gasik, M.; Silva, Filipe Samuel; Bartolomeu, FlávioIn this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V-and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 mu m and 100 mu m, respectively. Bioactive beta-tricalcium phosphate (beta TCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were ch...
Pathophysiology and therapeutic approaches for spinal cord injury
Lima, Rui Augusto Ribeiro; Monteiro, Andreia; Salgado, A. J.; Monteiro, Susana Isabel Gonçalves; Silva, Nuno André MartinsSpinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic functions. Despite extensive research in the last decades, SCI continues to be a global health priority affecting thousands of individuals every year. The lack of effective therapeutic strategies for patients with SCI reflects its complex pathophysiology that leads to the point of no return in its function repair and r...
Preclinical assessment of mesenchymal-stem-cell-based therapies in spinocerebel...
Correia, Joana Sofia Silva; Carvalho, Andreia Alexandra Neves; Pinheiro, Bárbara Filipa Mendes; Pires, Joel Pereira; Teixeira, Fábio Gabriel RodriguesThe low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies for neurodegenerative diseases, including spinocerebellar ataxias. Spinocerebellar ataxia type 3 (SCA3)—or Machado–Joseph disease (MJD)—is the most common dominant ataxia, being mainly characterized by motor deficits; however, SCA3/MJD has a complex and heterogeneous pathop...
Development of β-TCP-Ti6Al4V structures: driving cellular response by modulatin...
Costa, M. M.; Lima, Rui Augusto Ribeiro; Fonseca, Francisca Rocha Melo; Bartolomeu, Flávio; Alves, N.; Miranda, Alice Augusta Macedo; Gasik, M.Load-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive material is being absorbed and replaced by newly formed bone. In t...
Systemic interleukin-4 administration after spinal cord injury modulates inflam...
Lima, Rui Augusto Ribeiro; Monteiro, Susana Isabel Gonçalves; Lopes, José Luís Pimenta; Barradas, Pedro; Vasconcelos, Natália L.Traumatic spinal cord injury (SCI) causes dramatic disability and dysfunction in the motor, sensory and autonomic systems. The severe inflammatory reaction that occurs after SCI is strongly associated with further tissue damage. As such, immunomodulatory strategies have been developed, aimed at reducing inflammation, but also at shaping the immune response in order to protect, repair and promote regeneration of...
Bioengineered cell culture systems of central nervous system injury and disease
Teixeira, Fábio Gabriel Rodrigues; Vasconcelos, Natália L.; Gomes, Eduardo Domingos Correia; Marques, Fernanda; Sousa, João Carlos; Sousa, NunoCell culture systems, either 2D or explant based, have been pivotal to better understand the pathophysiology of several central nervous system (CNS) disorders. Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups. These innovative systems often combine different cell populations in 3D environments that more closely recapitulate the different niches that exi...
Desenvolvimento de revestimentos de nanopartículas para administração oral
Lima, Rui Augusto RibeiroA administração oral é a via de administração de fármacos mais cómoda para o paciente e que apresenta maior adesão à terapêutica. Permite ao paciente a ausência do ambiente hospitalar, conferindo a este um maior conforto. A utilização de nanopartículas é uma mais-valia para o tratamento de diversas patologias, permitindo a otimização da utilização dos fármacos através do seu direcionamento específico para as zo...