14 documents found, page 1 of 2

Massive Blood Loss from Urethrorrhage in a 16-year-old boy: Case Report and Rev...

Urethral varices and hemangiomas are rare, underreported conditions that can be asymptomatic or present with intermittent urethrorrhage that can start or worsen with erection, sexual intercourse and ejaculation. Diagnosis can be made with urethroscopy and there are a wide variety of possible treatments that can suit both conditions. We present a case of a pediatric patient with severe blood loss from urethral v...

The role of outer membrane protein(S) harboring slh/oprb-domains in extracellul...

Cyanobacteria are a group of photosynthetic prokaryotes that contribute to primary production on a global scale. These microorganisms release vesicles to the extracellular environment, spherical nanosized structures, derived essentially from the outer membrane. Even though earlier works in model Gram-negative bacteria have hypothesized that outer membrane stability is crucial in vesicle formation, the mechanism...

Extracellular vesicles: An overlooked secretion system in cyanobacteria

In bacteria, the active transport of material from the interior to the exterior of the cell, or secretion, represents a very important mechanism of adaptation to the surrounding environment. The secretion of various types of biomolecules is mediated by a series of multiprotein complexes that cross the bacterial membrane(s), each complex dedicated to the secretion of specific substrates. In addition, biological ...

Modified Arthroscopic McLaughlin Procedure in the Treatment of Posterior Glenohu...

The diagnosis of and the treatment for traumatic posterior shoulder dislocation are challenging. Some series describe that between 60 and 80% of these lesions are not diagnosed during the first visit to the emergency room. As such, dislocations are frequently found after several days or even weeks, adding complexity to their treatment. Posterior dislocations are usually accompanied by a print fracture on the ant...

Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepa...

Background: Neurosarcoidosis is a rare manifestation of hepatitis C virus (HCV) infection, mainly in patients exposed to interferon-based therapies. Although we are living in a new era of HCV treatment, there is still little data concerning the treatment of extrahepatic complications of the disease with direct antiviral agents, especially rare ones such as neurosarcoidosis. Summary: We present a rare case of ce...

Mannosylated solid lipid nanoparticles for the selective delivery of rifampicin...

Tuberculosis (TB) is still a devastating disease and more people have died of TB than any other infectious diseases throughout the history. The current therapy consists of a multidrug combination in a long-term treatment, being associated with the appearance of several adverse effects. Thus, solid lipid nanoparticles (SLNs) were developed using mannose as a lectin receptor ligand conjugate for macrophage target...

Ventilação Não Invasiva: Três Anos de Experiência de Uma Unidade de Cuidados In...

Introdução: A ventilação não invasiva tem sido utilizada de forma crescente em crianças com insuficiência respiratória aguda,evitando as complicações associadas à ventilação invasiva. Pretendeu-se descrever a experiência de ventilação não invasiva numa unidade de cuidados intermédios e avaliar a sua eficácia em evitar a transferência das crianças para uma unidade de cuidados intensivos pediátricos. Métodos: Est...

Development and validation of HPLC method with fluorometric detection for quant...

A simple, sensitive and specific high-performance liquid chromatography method for the quantification of bisnaphthalimidopropyldiaminooctane (BNIPDaoct), a potent anti-Leishmania compound, incorporated into poly(D,L-lactide-co-glycolic acid) (PLGA) nanoparticles was developed and validated toward bioanalysis application. Biological tissue extracts were injected into a reversed-phase monolithic column coupled to...

Surface functionalization of polymeric nanospheres modulates macrophage activat...

To characterize the production and application of carbohydrate functionalized poly(d,l-lactide-co-glycolide) (PLGA) nanospheres as immune-modulatory mediators in the treatment of visceral leishmaniasis (VL). Materials & methods: PLGA nanospheres were prepared by nanoprecipitation and surface functionalized with mannose, mannan or mannosamine moieties using a carbodiimide reaction. Flow cytometry and fluorescenc...

Hipoglicémia refratária no adulto: desafio diagnóstico a propósito de um caso c...