32 documents found, page 1 of 4
High VEGFA expression Is associated with improved progression-free survival aft...
Alves, Bárbara; Peixoto, Joana; Macedo, Sofia; Pinheiro, Jorge; Carvalho, Bruno; Soares, Paula; Lima, Jorge; Lima, Raquel T.Glioblastoma (GB) is a deadly tumor that demands for relevant biomarkers, particularly regarding patients’ response to treatment. MMP-2, MMP-9, VEGFA, and YKL40 are important molecules, given their implication in the infiltrative and angiogenic phenotype of GBs. The purpose of this study was to assess the relationship between the expression of MMP-2, MMP-9, VEGFA, and YKL40 in GB tissues and the patients’ respo...
Targeting mitochondrial TERT to overcome therapeutic resistance
Chantre, Ana; Correia, Marcelo; Soares, Paula; Máximo, Valdemar; Lima, Raquel T.Reactivation of telomerase is a common process in most human tumours [1, 2], usually due to reexpression of its catalytic subunit, the telomerase reverse transcriptase (TERT), contributing to cell immortalization [3]. In thyroid cancer (TC), it was demonstrated that TERT reactivation is often associated with distant metastases, therapy resistance and shorter survival rates of patients [4], however TERTs’ canoni...
Assessing the antitumor potential of variants of the extracellular carbohydrate...
Mota, Rita; Lima, Raquel T.; Flores, Carlos; Silva, Juliana F.; Cruz, Beatriz; Alves, Bárbara; Pinto, Marta T.; Adessi, Alessandra; Pereira, Sara B.Cancer is a leading cause of death worldwide with a huge societal and economic impact. Clinically effective and less expensive anticancer agents derived from natural sources can help to overcome limitations and negative side effects of chemotherapy and radiotherapy. Previously, we showed that the extracellular carbohydrate polymer of a Synechocystis ΔsigF overproducing mutant displayed a strong antitumor activi...
The cell growth inhibitory effect of an aqueous extract of Tuberaria lignosa in...
Pereira, Joana M.; Rodrigues, V.L.; Xavier, Cristina; Lima, M. João; Lima, Raquel T.; Ferreira, Isabel C.F.R.; Vasconcelos, M. HelenaTuberaria lignosa (Sweet) Samp. is found in European regions. This plant has antioxidant properties due to its composition in ascorbic acid and phenolic compounds [1]. Given its antioxidant properties and its large traditional use, the aim of this work was to study the tumor cell growth inhibitory potential of aqueous extracts from T. lignosa (prepared by infusion and decoction). Cell growth was accessed by the...
Suppression of spindly delays mitotic exit and exacerbates cell death response ...
Silva, Patrícia M. A.; Ribeiro, Nilza; Lima, Raquel T.; Andrade, Claudia; Diogo, Vania; Teixeira, Joana; Florindo, C.; Tavares, AlvaroMicrotubule-targeting agents (MTAs) are used extensively for the treatment of diverse types of cancer. They block cancer cells in mitosis through the activation of the spindle assembly checkpoint (SAC), the surveillance mechanism that ensures accurate chromosome segregation at the onset of anaphase. However, the cytotoxic activity of MTAs is limited by premature mitotic exit (mitotic slippage) due to SAC silenc...
An aqueous extract of tuberaria lignosa inhibits cell growth, alters the cell c...
Pereira, Joana M.; Lopes-Rodrigues, Vanessa; Xavier, Cristina; Lima, M. João; Lima, Raquel T.; Ferreira, Isabel C.F.R.; Vasconcelos, M. HelenaTuberaria lignosa (Sweet) Samp. is found in European regions, and has antioxidant properties due to its composition in ascorbic acid and phenolic compounds. Given its traditional use and antioxidant properties, the tumor cell growth inhibitory potential of aqueous extracts from T. lignosa (prepared by infusion and decoction) was investigated in three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H4...
Can macroalgae provide promising anti-tumoral compounds? A closer look at Cysto...
Vizetto-Duarte, C; Custódio, Luísa; Acosta, Gerardo; Lago, João H. G.; Morais, Thiago R.; Sousa, Carolina Bruno de; Gangadhar, Katkam N.Marine organisms are a prolific source of drug leads in a variety of therapeutic areas. In the last few years, biomedical, pharmaceutical and nutraceutical industries have shown growing interest in novel compounds from marine organisms, including macroalgae. Cystoseira is a genus of Phaeophyceae (Fucales) macroalgae known to contain bioactive compounds. Organic extracts (hexane, diethyl ether, ethyl acetate and...
Study of the cell growth inhibitory effect of aqueous extracts from Tuberaria l...
Pereira, J.; Rodrigues, V.L.; Lima, M. João; Lima, Raquel T.; Ferreira, Isabel C.F.R.; Vasconcelos, M. HelenaTuberaria lignosa (Sweet) Samp. (“alcária”), a plant mostly found in Western regions of the Iberian Peninsula, has antioxidant properties due to its composition in ascorbic acid and phenolic compounds [1]. Given these antioxidant properties, together with the traditional use of the plant to treat several diseases, the aims of this work were to: i) investigate if aqueous extracts from this plant, obtained by inf...
Methanolic extract of Ganoderma lucidum induces autophagy of AGS human gastric ...
Reis, Filipa S.; Lima, Raquel T.; Morales, Patricia; Ferreira, Isabel C.F.R.; Vasconcelos, M. HelenaGanoderma lucidum is one of the most widely studied mushroom species, particularly in what concerns its medicinal properties. Previous studies (including those from some of us) have shown some evidence that the methanolic extract of G. lucidum affects cellular autophagy. However, it was not known if it induces autophagy or decreases the autophagic flux. The treatment of a gastric adenocarcinoma cell line (AGS) ...
Cordyceps militaris (L.) Link fruiting body reduces the growth of a non-small c...
Bizarro, Ana; Ferreira, Isabel C.F.R.; Soković, Marina; Van Griensven, Leo J.L.D.; Sousa, Diana; Vasconcelos, M. Helena; Lima, Raquel T.Cordyceps militaris (L.) Link, an edible entomopathogenic fungus widely used in traditional Chinese medicine, has numerous potential medicinal properties including antitumor activity. The methanolic extract of C. militaris fruiting body was recently shown to have tumor cell growth inhibitory activity in several human tumor cell lines. Nonetheless, the mechanism of action involved is still not known. This work a...