6 documents found, page 1 of 1
Synthesis and Antioxidant and Antimicrobial Properties of β-Hydroxy Sulfides, S...
Copini,Suély; Micheletti,Ana C.; Lima,Dênis P. de; Gomes,Roberto S.; Meza,Alisson; Beatriz,AdilsonNatural and synthetic sulfur-bearing organic compounds have many applications in medicinal chemistry. This article reports the preparation of amphiphilic β-hydroxy sulfides, sulfoxides, and sulfones derived from cardanol and glycerol. Thiolysis of cardanol epoxide 3 with various thiols (4a-4j) in ethanol or water yielded the corresponding β-hydroxy sulfides 5a-5j (61-95%). Treatment with 30% H2O2 in acetic acid...
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol...
Manda,Bhaskar R.; Prasad,Avvari N.; Thatikonda,Narendar R.; Lacerda Jr.,Valdemar; Barbosa,Layla R.; Santos,Heloa; Romão,Wanderson; Pavan,Fernando R.The synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by 1H and 13C NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. ...
Synthesis and evaluation of octocrylene-inspired compounds for UV-filter activity
Polonini,Hudson C.; Lopes,Rosângela S.; Beatriz,Adilson; Gomes,Roberto S.; Silva,Adriano O.; Lima,Ricardo V. de; Nunes,Gláucia. A.Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) r...
Synthesis and biological activity of sulfur compounds showing structural analog...
Santos,Edson dos A. dos; Prado,Paulo C.; Carvalho,Wanderley R. de; Lima,Ricardo V. de; Beatriz,Adilson; Lima,Dênis P. de; Hamel,Ernest; Dyba,Marzena A.We extended our previous exploration of sulfur bridges as bioisosteric replacements for atoms forming the bridge between the aromatic rings of combretastatin A-4. Employing coupling reactions between 5-iodo-1,2,3-trimethoxybenzene and substituted thiols, followed by oxidation to sulfones with m-CPBA, different locations for attaching the sulfur atom to ring A through the synthesis of nine compounds were examine...
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Mahmoud,Talal Suleiman; Marques,Maria Rita; Pessoa,Cláudia do Ó; Lotufo,Leticia V. C.; Magalhães,Hemerson I. F.; Moraes,Manoel O. de; Lima,Dênis P. deCytotoxic activity of eight plant extracts, native from the Mid-West of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL-1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL-1) was used as the positive control and the MTT method was used to detect the activity. Cytotoxi...
Bioprospecting insecticidal compounds from plants native to Mato Grosso do Sul,...
Souza,Antonio P.; Marques,Maria R.; Mahmoud,Talal S.; Caputo,Bruno A.; Canhete,Gabriel M.; Leite,Carla B.; Lima,Dênis P. deThis paper reports on an evaluation of the insecticidal activity of extracts prepared from leaves of Tapirira guianensis Aubl. (Anacardiaceae), Attalea phalerata (Mart. ex Spreng.) Burret (Arecaceae), Eugenia uniflora L. (Myrtaceae), and Gomphrena elegans Mart. (Amaranthaceae) and from stems of Myracrodruon urundeuva Allemão (Anacardiaceae). Four extracts and 18 fractions with a range of polarities were tested....