2 documents found, page 1 of 1
Synthesis and evaluation of octocrylene-inspired compounds for UV-filter activity
Polonini,Hudson C.; Lopes,Rosângela S.; Beatriz,Adilson; Gomes,Roberto S.; Silva,Adriano O.; Lima,Ricardo V. de; Nunes,Gláucia. A.Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) r...
Synthesis and biological activity of sulfur compounds showing structural analog...
Santos,Edson dos A. dos; Prado,Paulo C.; Carvalho,Wanderley R. de; Lima,Ricardo V. de; Beatriz,Adilson; Lima,Dênis P. de; Hamel,Ernest; Dyba,Marzena A.We extended our previous exploration of sulfur bridges as bioisosteric replacements for atoms forming the bridge between the aromatic rings of combretastatin A-4. Employing coupling reactions between 5-iodo-1,2,3-trimethoxybenzene and substituted thiols, followed by oxidation to sulfones with m-CPBA, different locations for attaching the sulfur atom to ring A through the synthesis of nine compounds were examine...