4 documents found, page 1 of 1
TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related int...
Wong, Deysi Viviana Tenazoa; Holanda, Renata Brito Falcão; Cajado, Aurilene Gomes; Bandeira, Alessandro Maia; Pereira, Jorge Fernando BessaMade available in DSpace on 2022-05-01T07:58:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico; Background and purpose: Severe diarrhoea, a common gastrointestinal manifestation of anticanc...
Role of regulatory T cells in irinotecan-induced intestinal mucositis
Fernandes, Camila; Wanderley, Carlos Wagner Souza; Silva, Camila Meireles Souza; Muniz, Heitor Amorim; Teixeira, Maraiza AlvesIntestinal mucositis (IM) is a common side effect of irinotecan-based chemotherapy. The involvement of inflammatory mediators, such as TNF-α, IL1-β, IL-18 and IL-33, has been demonstrated. However, the role of adaptive immune system cells, whose activation is partially regulated by these cytokines, is yet unknown. Thus, we investigated the role of regulatory T cells (Tregs) in irinotecan-induced IM. C57BL/6 mic...
Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced ...
Assis-Júnior, Eudmar Marcolino; Melo, Anielle Torres; Pereira, Venúcia Bruna Magalhães; Wong, Deysi Viviana Tenazoa; Sousa, Nathalia Ribeiro PinhoIrinotecan-based regimens are commonly used for treatment of colorectal cancer, which is limited by mucositis and non-alcoholic steatohepatitis (NASH). Silymarin (SIL) prevents fatty liver disease in the clinical setting and in models of liver damage induced chemically. This study investigated the possible effect of SIL on irinotecan (IRI)-induced NASH. Swiss female mice were injected with saline (SAL 5 ml/kg i...
Acute and neuropathic orofacial antinociceptive effect of eucalyptol
Melo Júnior, José de Maria de Albuquerque de; Damasceno, Marina de Barros Mamede Vidal; Santos, Sacha Aubrey Alves Rodrigues; Barbosa, Talita MatiasTerpenes have a wide range of pharmacological properties, including antinociceptive action. The anti-in- flammatory and antinociceptive effects of eucalyptol are well established. The purpose of this study was to evaluate the antinociceptive effect of eucalyptol on acute and neu- ropathic orofacial pain in rodent models. Acute orofacial and corneal nociception was induced with formalin, cap- saicin, glutamate a...