4 documents found, page 1 of 1
The alpha-lipoic acid improves survival and prevents irinotecan-induced inflamm...
Costa, Daniely V. S.; Costa, Deiziane V. S.; Sousa, Caren N. S.; Silva, Angeline M. H. P.; Medeiros, Ingridy S.; Martins, Dainesy S.Irinotecan, an anticancer drug, induces diarrhea and intestinal inflammation, resulting in an increase in the cost of care and in treatment delays. In this study, we investigated whether alpha-lipoic acid (α-LA) could improve irinotecan-mediated intestinal inflammation, diarrhea and dysmotility. Intestinal mucositis was induced by irinotecan injection (75 mg/kg, i.p., for 4 days) in Swiss mice. α-LA (50, 100 or...
5-Fluorouracil induces enteric neuron death and glial activation during intesti...
Costa, Deiziane V. S.; Bon-Frauches, Ana C.; Silva, Angeline M. H. P.; Lima-Júnior, Roberto C. P.; Martins, Conceição S.5-Fluorouracil (5-FU) is an anticancer agent whose main side effects include intestinal mucositis associated with intestinal motility alterations maybe due to an effect on the enteric nervous system (ENS), but the underlying mechanism remains unclear. In this report, we used an animal model to investigate the participation of the S100B/RAGE/NFκB pathway in intestinal mucositis and enteric neurotoxicity caused b...
The involvement of mast cells in the irinotecan-induced enteric neurons loss an...
Nogueira, Ludmila T.; Costa, Deiziane V. S.; Gomes, Antoniella Souza; Martins, Conceição S.; Silva, Angeline M. H. P.; Coelho-Aguiar, Juliana M.Background The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory mediators that can interact with the ENS cells. It has not been explored whether CPT-11 is able to alter the enteric glial and neuronal cell, and the role of mast cells in this effect. Therefore...
The adaptor protein myd88 is a key signaling molecule in the pathogenesis of ir...
Wong, Deysi V. T.; Lima-Júnior, Roberto C. P.; Carvalho, Cibele B. M.; Borges, Vanessa F.; Wanderley, Carlos W. S.; Bem, Amanda X. C.Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves the Myeloid Differentiation adaptor protein, MyD88, whose role in intestinal mucositis is unknown. Then, we evalu...