3 documents found, page 1 of 1
Amifostine reduces inflammation and protects against 5-fluorouracil-induced ora...
Barbosa, Sabrina Carneiro Melo; Pereira, Venúcia B.M.; Wong, Deysi V.T.; Santana, Ana P.M.; Lucetti, Larisse T.; Carvalho, Lucas L.Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) andradiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable.Amifostine is a cytoprotective agent with a described anti-inflammatory potential. It is clinically used to reduce radiotherapy andchemotherapy-associated xerostomia. Th...
Inhalation of the prodrug PI3K inhibitor CL27cimproves lung function in asthma ...
Campa, Carlo C.; Silva, Rangel L.; Margaria, Jean P.; Piral, Tracey; Mattos, Matheus S.; Kraemer, Lucas R.; Reis, Diego C.; Grosa, GiorgioPI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwanted on-target systemic toxicity. Here we present CL27c, a prodrug pan-PI3K inhibitor designed for local therapy, and investigate whether inhaled CL27c is effective i...
Clinical correlation between N-terminal pro-b-type natriuretic peptide and angi...
Ribeiro, Demóstenes G.L.; Silva, Ricardo P.; Barboza, Daniella R.M.M.; Lima-Júnior, Roberto C.P.; Ribeiro, Ronaldo A.OBJECTIVES: This study aimed to investigate the clinical correlation between angiographic coronary atherosclerosis and N-terminal pro-B-type natriuretic peptide along with other known correlated factors. METHODS: In total, 153 patients with a diagnostic hypothesis of stable angina, unstable angina or acute myocardial infarction were classified as group A (patients with angiographically normal coronary arteries)...