5 documents found, page 1 of 1
Thyroid cancer: The quest for genetic susceptibility involving dna repair genes
Santos, LS; Gomes, BC; Bastos, HN; Gil, OM; Azevedo, AP; Ferreira, TC; Limbert, E; Silva, SN; Rueff, JThe incidence of thyroid cancer (TC), particularly well-differentiated forms (DTC), has been rising and remains the highest among endocrine malignancies. Although ionizing radiation (IR) is well established on DTC aetiology, other environmental and genetic factors may also be involved. DNA repair single nucleotide polymorphisms (SNPs) could be among the former, helping in explaining the high incidence. To furth...
PROP1 gene analysis in Portuguese patients with combined pituitary hormone defi...
Lemos, MC; Gomes, L; Bastos, M; Leite, V; Limbert, E; Carvalho, D; Bacelar, C; Monteiro, M; Fonseca, F; Agapito, A; Castro, JJ; Regateiro, FJOBJECTIVE: Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS: A multicentric study involving 46 cases of CPHD (17 familial cases belonging to seven kindreds and...
PROP1 Gene Analysis in Portuguese Patients with Combined Pituitary Hormone Defi...
Lemos, MC; Gomes, L; Bastos, M; Leite, V; Limbert, E; Carvalho, D; Bacelar, C; Monteiro, M; Fonseca, F; Agapito, A; Castro, JJ; Regateiro, FOBJECTIVE: Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS: A multicentric study involving 46 cases of CPHD (17 familial cases belonging to seven kindreds and...
Lymphocytes from iodine-131 treated thyroid cancer patients undergo a transient...
Gil, OM; Oliveira, NG; Rodrigues, AS; Laires, A; Ferreira, TC; Limbert, E; Rueff, J
Assay of thyroglobulin in the study of patients with differentiated thyroid car...
Limbert, E; Dinarés, J M; Santos, M A; Henriques, M M