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Molecularly engineered self-assembling membranes for cell-mediated degradation
Ferreira , Daniela S.; Lin, Yi-An; Cui, Honggang; Hubbell, Jeffrey A.; Reis, R. L.; Azevedo, Helena S.The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a proteolytic domain (GPQGIWGQ octapeptide) sensitive to matrix metalloproteinase-1 (MMP-1). Insertion of an octapeptide in a typical PA structure does not disturb it...
Data: 2015
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Origem: RepositóriUM - Universidade do Minho