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Gerir a doença pulmonar obstrutiva crónica em cuidados de saúde primários: impa...
Oliveira, Guilherme; Félix, Rita; Ruivo dos Santos, Pedro; ´Monteiro, Luís; Tejo, Cristina; Oliveira, Guilherme; Oliveira, Guilherme; Félix, RitaIntrodução: A doença pulmonar obstrutiva crónica (DPOC) é a terceira causa de mortalidade a nível global. O tratamento foca-se na melhoria da qualidade de vida, atraso da progressão da doença e redução das exacerbações. Neste contexto, o benefício da reabilitação respiratória tem vindo a ser verificado. Esta medida não farmacológica pode ser implementada na comunidade, no contexto dos cuidados de saúde primário...
Expanding the toolbox of four-membered rings to study Serine hydrolases
Félix, RitaSerine hydrolases comprise nearly 1% of all proteins in mammalian cells and play vital roles in relevant pathologies such as cancer and chronic inflammatory diseases. Human Neutrophil Elastase (HNE), a serine hydrolase expressed in polymorphonuclear neutrophiles, is present in the tumour microenvironment and recent studies have shown it promotes tumour proliferation and metastasis. The role of HNE in the tumour...
A Gonorrhea: a brief history of evolution: A brief history of the evolution of ...
Félix, Rita; Machado, Cátia; Damião, Pedro
Sensory and motor representations in the inferior olive of larval zebrafish
Félix, Rita"The olivo-cerebellar system plays a pivotal role in sensorimotor con- trol and coordination in vertebrates. According to a classical theory of cerebellar cortex, the inferior olive (IO) provides Purkinje cells with error information which drives motor learning in the cerebellum. Even though this process has been extensively studied over the last five decades, it re- mains unclear whether the nature of IO signa...
Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations...
Nunes, Andreia; Marto, Joana; Gonçalves, Lídia; Simões, Sandra; Félix, Rita; Ascenso, Andreia; Lopes, Francisca; Ribeiro, HelenaHuman neutrophil elastase (HNE) is a serine protease that degrades matrix proteins. An excess of HNE may trigger several pathological conditions, such as psoriasis. In this work, we aimed to synthesize, characterize and formulate new HNE inhibitors with a 4-oxo-β-lactam scaffold with less toxicity, as well as therapeutic index in a psoriasis context. HNE inhibitors with 4-oxo-β-lactam scaffolds were synthesized...